An Explicit Review on Quantitative Estimation of Candesartan Cilexetil Employing Various Analytical Techniques
- *Corresponding Author:
- Shantanu Bandyopadhyay
University Institute of Pharmaceutical Sciences
UGC Centre of Advanced Studies, Panjab University
Chandigarh 160 014, India
E-mail: [email protected]
Received date: June 11, 2013; Accepted date: June 20, 2013; Published date: June 25, 2013
Citation: Bandyopadhyay S, Bhuria L, Lal D (2013) An Explicit Review on Quantitative Estimation of Candesartan Cilexetil Employing Various Analytical Techniques. Pharm Anal Acta 4:254. doi: 10.4172/2153-2435.1000254
Copyright: © 2013 Bandyopadhyay S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Angiotensin II Receptor type 1 antagonists have been widely used in treatment of various disorders like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Over the years, varied analytical methods were developed both in biological fluids as well as dosage forms in order to estimate their desired pharmacological activity. Candesartan being highly lipohpilic with variable oral bioavailability, its estimation in biological fluids is very critical for establishing its subsequent therapeutic efficacy. A few UV spectrophotometeric and volatmmetric techniques have been reported to estimate candesartan in bulk formulations. Additionally, capillary electrophoresis methods provided qualitative and quantitative estimation of candesartan with a few methods being systematically optimized using experimental designs. Ultimately, an overview of different HPLC and LC-MS/MS methods explained the importance of the methods while estimating candesartan in various biological fluids (e.g. plasma, urine, etc.) as well as other studies like, stability studies. This review provides a bird’s eye-view on the various analytical techniques employed for determination of candesartan in both in vitro and in vivo conditions.