alexa An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels
ISSN: 2329-6771

Journal of Integrative Oncology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels

Brian I Carr1*, Vito Guerra2, Edoardo G. Giannini3, Fabio Farinati4, Francesca Ciccarese5, Gian Ludovico Rapaccini6, Maria Di Marco7, Luisa Benvegnù8, Marco Zoli9, Franco Borzio10, Eugenio Caturelli11, Alberto Masotto12 and Franco Trevisani13

1Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey

2Department of Clinical Trials and Epidemiology, IRCCS de Bellis, Castellana Grotte, Italy

3Departiment of Internal Medicine, Gastroenterology Unit, University of Genoa, Italy

4Departiment of Surgical Science and Gastroenterology, Gastroenterology Unit, University of Padua, Italy

5Division of Surgery, Policlinico San Marco, Zingonia, Italy

6Internal Medicine and Gastroenterology Unit, Catholic University of Rome, Italy

7Division of Medicine, Azienda Ospedaliera Bolognini, Seriate, Italy

8Departiment of Clinical and Experimental Medicine, Medical Unit, University of Padua, Italy

9Department of Medical and Surgical Science, Internal Medicine Unit, Alma Mater Studiorum, University of Bologna, Italy

10Department of Medicine, Internal Medicine and Hepatology Unit, Ospedale Fatebenefratelli, Milan, Italy

11Gastroenterology Unit, Ospedale Belcolle, Viterbo, Italy

12Gastroenterology Unit, Ospedale Sacro Cuore Don Calabria, Negrar, Italy

13Department of Medical Surgical Sciences, Medical Semiotics Unit, Alma Mater Studiorum, University of Bologna, Italy

*Corresponding Author:
Brian I Carr
Visiting Professor, Program for Targeted Experimental Therapeutics
Izmir Biomedicine and Genome Center
Dokuz Eylul University, Izmir, Turkey.
Tel: 1 412 980 4518
E-mail: [email protected]

Received date: May 17, 2016; Accepted date: June 14, 2016; Published date: June 20, 2016

Citation: Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, et al. (2016) An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels. J Integr Oncol 5:172. doi:10.4172/2329-6771.1000172

Copyright: © 2016 Carr BI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Four HCC characteristics typically inform tumor behavior: maximum tumor size, number of nodules, portal vein thrombosis and serum AFP level. The sum of these parameters was recently published as an HCC Aggressiveness Index. We aimed to validate this index retrospectively in a larger and independent HCC cohort of 2706 Italian HCC patients, and to evaluate a possible relationship between the index and liver function parameters. The scores in the HCC Aggressiveness Index were again found to significantly relate to patient survival. Furthermore, in a multiple logistic regression model of the Aggressiveness Index score categories, there were significant differences in several liver parameter terciles amongst the score categories, suggesting a relationship of liver function to tumor aggressiveness. It was concluded that a prognostically significant Tumor Aggressiveness Index was validated and was found to be related to levels of some common liver function parameters.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version