alexa An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels
ISSN: 2329-6771

Journal of Integrative Oncology
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Research Article

An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels

Brian I Carr1*, Vito Guerra2, Edoardo G. Giannini3, Fabio Farinati4, Francesca Ciccarese5, Gian Ludovico Rapaccini6, Maria Di Marco7, Luisa Benvegnù8, Marco Zoli9, Franco Borzio10, Eugenio Caturelli11, Alberto Masotto12 and Franco Trevisani13

1Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey

2Department of Clinical Trials and Epidemiology, IRCCS de Bellis, Castellana Grotte, Italy

3Departiment of Internal Medicine, Gastroenterology Unit, University of Genoa, Italy

4Departiment of Surgical Science and Gastroenterology, Gastroenterology Unit, University of Padua, Italy

5Division of Surgery, Policlinico San Marco, Zingonia, Italy

6Internal Medicine and Gastroenterology Unit, Catholic University of Rome, Italy

7Division of Medicine, Azienda Ospedaliera Bolognini, Seriate, Italy

8Departiment of Clinical and Experimental Medicine, Medical Unit, University of Padua, Italy

9Department of Medical and Surgical Science, Internal Medicine Unit, Alma Mater Studiorum, University of Bologna, Italy

10Department of Medicine, Internal Medicine and Hepatology Unit, Ospedale Fatebenefratelli, Milan, Italy

11Gastroenterology Unit, Ospedale Belcolle, Viterbo, Italy

12Gastroenterology Unit, Ospedale Sacro Cuore Don Calabria, Negrar, Italy

13Department of Medical Surgical Sciences, Medical Semiotics Unit, Alma Mater Studiorum, University of Bologna, Italy

*Corresponding Author:
Brian I Carr
Visiting Professor, Program for Targeted Experimental Therapeutics
Izmir Biomedicine and Genome Center
Dokuz Eylul University, Izmir, Turkey.
Tel: 1 412 980 4518
E-mail: [email protected]

Received date: May 17, 2016; Accepted date: June 14, 2016; Published date: June 20, 2016

Citation: Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, et al. (2016) An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels. J Integr Oncol 5:172. doi:10.4172/2329-6771.1000172

Copyright: © 2016 Carr BI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Four HCC characteristics typically inform tumor behavior: maximum tumor size, number of nodules, portal vein thrombosis and serum AFP level. The sum of these parameters was recently published as an HCC Aggressiveness Index. We aimed to validate this index retrospectively in a larger and independent HCC cohort of 2706 Italian HCC patients, and to evaluate a possible relationship between the index and liver function parameters. The scores in the HCC Aggressiveness Index were again found to significantly relate to patient survival. Furthermore, in a multiple logistic regression model of the Aggressiveness Index score categories, there were significant differences in several liver parameter terciles amongst the score categories, suggesting a relationship of liver function to tumor aggressiveness. It was concluded that a prognostically significant Tumor Aggressiveness Index was validated and was found to be related to levels of some common liver function parameters.

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