An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels
Brian I Carr1*, Vito Guerra2, Edoardo G. Giannini3, Fabio Farinati4, Francesca Ciccarese5, Gian Ludovico Rapaccini6, Maria Di Marco7, Luisa Benvegnù8, Marco Zoli9, Franco Borzio10, Eugenio Caturelli11, Alberto Masotto12 and Franco Trevisani13
- *Corresponding Author:
- Brian I Carr
Visiting Professor, Program for Targeted Experimental Therapeutics
Izmir Biomedicine and Genome Center
Dokuz Eylul University, Izmir, Turkey.
Tel: 1 412 980 4518
E-mail: [email protected]
Received date: May 17, 2016; Accepted date: June 14, 2016; Published date: June 20, 2016
Citation: Carr BI, Guerra V, Giannini EG, Farinati F, Ciccarese F, et al. (2016) An HCC Aggressiveness Index and Blood GTP, Bilirubin and Platelet Levels. J Integr Oncol 5:172. doi:10.4172/2329-6771.1000172
Copyright: © 2016 Carr BI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Four HCC characteristics typically inform tumor behavior: maximum tumor size, number of nodules, portal vein thrombosis and serum AFP level. The sum of these parameters was recently published as an HCC Aggressiveness Index. We aimed to validate this index retrospectively in a larger and independent HCC cohort of 2706 Italian HCC patients, and to evaluate a possible relationship between the index and liver function parameters. The scores in the HCC Aggressiveness Index were again found to significantly relate to patient survival. Furthermore, in a multiple logistic regression model of the Aggressiveness Index score categories, there were significant differences in several liver parameter terciles amongst the score categories, suggesting a relationship of liver function to tumor aggressiveness. It was concluded that a prognostically significant Tumor Aggressiveness Index was validated and was found to be related to levels of some common liver function parameters.