alexa An Insight in to the Pathogenesis of Diabetic Vascular
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Review Article

An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants

Aditi1,Nipun Mahajan2,Shruti Rawal3 and Rajesh Katare3*

1Department of Pharmacology, Lovely School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

2Nipun Mahajan, School of Chemistry, National University of Ireland, Galway, Ireland

3Department of Physiology, Otago School of Medical Sciences, University of Otago, New Zealand

*Corresponding Author:
Rajesh Katare
Department of Physiology Heart Otago
Otago School of Medical Sciences
University of Otago, New Zealand
Tel: +64-3-4797292
Fax: +64-3-4797323
E-mail: [email protected]

Received date: October 18, 2013; Accepted date: November 25, 2013; Published date: November 27, 2013

Citation: Aditi, Mahajan N, Rawal S, Katare R (2013) An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants. Pharmaceut Anal Acta 4:273. doi: 10.4172/2153-2435.1000273

Copyright: © 2013 Aditi, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The profound effects of hyperglycaemia on the vascular tree are the major causes of morbidity and mortality among patients suffering from diabetes. Diabetic Vascular Diseases (DVD) includes accelerated forms of atherosclerosis due to endothelial dysfunction and microangiopathy of retinal vessels. A host of several studies indicate that increased oxidative stress play a pivotal role in the development and progression of diabetic vascular diseases. The metabolic abnormalities due to oxidative stress are linked to the structural and functional changes in the vasculature, consequently resulting in atherosclerosis and diabetic retinopathy. Oxidative stress brings alterations in downstream transcription factors which result in changes in gene expression, myocardial substrate utilization, myocyte growth, endothelial function and myocardial compliance. Based on this, an approach towards investigating new and effective antioxidant therapies could serve as potential therapeutic implications in preventing the deleterious effects of oxidative stress on vasculature. This review aims to understand the underlying mechanisms involved in the pathogenesis of vascular complications in diabetes with special emphasis on the role of oxidative stress towards development of these complications and also describe the role of antioxidants as therapeutic interventions for DVD.

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