An Insight into Podoplanin Ã¢ÂÂ Emphasizing its Role in Oral DiseasesBina Kashyap1* and Sridhar Reddy P2
- *Corresponding Author:
- Kashyap B
Associate Professor Department of Oral Pathology
Buraydah Private Dental College
Buraydah, Saudi Arabia
Tel: 966 504663028,
E-mail: [email protected].in
Received Date: April 24, 2015; Accepted Date: May 25, 2015; Published Date: May 27, 2015
Citation: Bina Kashyap, Sridhar Reddy (2015) An Insight into Podoplanin – Emphasizing its Role in Oral Diseases. J Clin Exp Pathol 5:230. doi: 10.4172/2161-0681.1000230
Copyright: © 2015 Kashyap B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cancer is a heterogeneous and multistep disease process involving dysregulation of multiple pathways linked to cellular differentiation, cell cycle control, apoptosis, angiogenesis, and metastasis. Multiple genetic alterations causes’ unregulated proliferation of cells, influenced by genetic predisposition as well as by environmental influences, including tobacco, alcohol, chronic inflammation and viral infections. Most of the cancers arises de novo or is often preceded by potentially malignant disorders such as leukoplakia and OSMF. The potentially malignant disorders have shown to have a high risk of malignant transformation, on average about one percent of oral lesions transform into cancer annually .