alexa An Investigation of Hepatoprotective Activity of Methanolic Extract of Ipomoea reniformis on Experimentally Induced Ethanol Hepatotoxicity in Rats
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

An Investigation of Hepatoprotective Activity of Methanolic Extract of Ipomoea reniformis on Experimentally Induced Ethanol Hepatotoxicity in Rats

Neelima S*, Pradeep Kumar M and Hari Kumar C

Vasavi Institute of Pharmaceutical Sciences, Kadapa, Andhra Pradesh, India

*Corresponding Author:
Neelima S
Vasavi Institute of Pharmaceutical Sciences
Kadapa-516247, Andhra Pradesh, India
Tel: +91-9701511457
E-mail: [email protected]

Received Date: November 29, 2016; Accepted Date: December 23, 2016; Published Date: January 02, 2017

Citation: Neelima S, Pradeep Kumar M, Hari Kumar C (2017) An Investigation of Hepatoprotective Activity of Methanolic Extract of Ipomoea reniformis on Experimentally Induced Ethanol Hepatotoxicity in Rats. Clin Exp Pharmacol 7:227. doi: 10.4172/2161-1459.1000227

Copyright: © 2017 Neelima S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: The present study evaluated the hepatoprotective activity of Methanolic Extract of Ipomoea reniformis (MEIR) in experimentally-induced hepatotoxic rats. Methods: Hepatoprotective activity of MEIR was studied against ethanol (4 g/kg p.o.)-induced hepatotoxicity rats. Silymarin (100 mg/kg p.o.) was used as a standard reference. The following parameters were evaluated; serum biomarkers such as Serum Glutamate Oxaloacetic Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), total and direct bilirubin, Total Protein (TP) and tissue antioxidant levels such as Glutathione (GSH) and Lipid Peroxidation (LPO). Results and conclusion: The control group did not exhibit increase in serum parameters, but ethanol toxicant group showed significant increase in serum parameters such as SGOT, SGPT, bilirubin (total and direct), and LPO, whereas GSH and TP levels were markedly reduced. Silymarin, MEIR low dose (200 mg/kg p.o.) and high dose (400 mg/kg p.o.) treated groups showed significant decrease in SGOT, SGPT, total and direct bilirubin, TB, LPO and increase in GSH and TP levels. Based on the study findings in serum marker enzyme levels and antioxidant parameters, it is concluded that MEIR possesses hepatoprotective activity.

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