alexa An Optimal Approach for Fluoroquinolone Garenoxacin Prophylaxis in Patients with Hematological Malignancies and Chemotherapy-induced Neutropenia
ISSN: 2165-7831

Journal of Blood & Lymph
Open Access

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Research Article

An Optimal Approach for Fluoroquinolone Garenoxacin Prophylaxis in Patients with Hematological Malignancies and Chemotherapy-induced Neutropenia

Mushino T1#, Hanaoka N1,2*,#, Murata S1, Kuriyama K1, Hosoi H1, Nishikawa A1, Tamura S1, Nakakuma H1,2 and Sonoki T1

1Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan

2Department of Internal Medicine, Kagoshima Tokushukai Hospital, Kagoshima, Japan

#Mushino T and Hanaoka N contributed equally.

*Corresponding Author:
Hanaoka N
Department of Hematology/Oncology
Wakayama Medical University
811-1 Kimiidera, Wakayama 641-8510, Japan
Tel: +81 73 4410665
Fax: +81 73 4410653
E-mail: [email protected]

Received Date: March 21, 2017; Accepted Date: April 10, 2017; Published Date: April 12, 2017

Citation: Mushino T, Hanaoka N, Murata S, Kuriyama K, Hosoi H, et al. (2017) An Optimal Approach for Fluoroquinolone Garenoxacin Prophylaxis in Patients with Hematological Malignancies and Chemotherapy-induced Neutropenia. J Blood Lymph 7: 161. doi: 10.4172/2165-7831.1000161

Copyright: © 2017 Mushino T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Antibiotic prophylaxis such as that with fluoroquinolone reportedly reduces infectious episodes in patients receiving chemotherapy regimens with the risk of febrile neutropenia. However, optimum patient characteristics, the timing of initiation, and antibiotics for prophylactic treatments have yet to be identified. We herein conducted a single-arm monocenter clinical study to elucidate the therapeutic profiles of fluoroquinolone garenoxacin prophylaxis for patients with hematological malignancies (HMs). Fever was not present for the duration of chemotherapyinduced neutropenia in 29 (43.9%) out of 66 patients. A shorter duration of prophylaxis until chemotherapy-induced neutropenia had a more potent effect on delaying febrile episodes, even in patients with fever. Excessive neutropenia (minimum zero neutrophils/l) negatively affected prophylactic effects. Garenoxacin accounted for 4.5% of the minor adverse events observed such as mild renal damage and skin reactions. Therefore, the study suggests that the initiation of garenoxacin prophylaxis from the introduction of neutropenia could be an effectual strategy for preventing chemotherapy-induced febrile episodes in HM patients with moderate neutropenia.

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