alexa An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids | OMICS International | Abstract
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Review Article

An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids

Naveed S*

Faculty of Pharmacy, Research institute of pharmaceutical Sciences, University of Karachi, Pakistan

*Corresponding Author:
Naveed S
Faculty of Pharmacy
Research institute of pharmaceutical Sciences
University of Karachi, Pakistan
Tel: 0092-3002621917
E-mail: [email protected]

Received Date: October 23, 2013; Accepted Date: November 22, 2013; Published Date: November 29, 2013

Citation: Naveed S (2013) An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids. J Bioequiv Availab 5:264-266. doi: 10.4172/jbb.1000171

Copyright: © 2013 Naveed S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Present review article determine the analytical methods for the quantitative determinations of Captopril (ACE Inhibitor) by one of the spectroscopic technique (UV spectrophotometery) and separation technique such as High- Performance Liquid chromatography (HPLC). The clinical and pharmaceutical analysis of captopril requires effective analytical procedures for quality control, Pharmaceuticals dosage formulations and human serum. An extensive survey of the research articles published in various pharmaceutical, clinical and analytical chemistry related journals has been compiled in this paper. A synopsis of reported spectrophotometer and high-performance liquid chromatographic methods for captopril are integrated. This appraisal illustrate that majority of the HPLC methods reviewed are based on the quantitative analysis of drug in active Pharmaceutical ingredients (API) biological fluids such as serum and plasma and they are appropriate for therapeutic drug monitoring , pharmacokinetic purpose.

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