alexa An Overview of P450 Enzymes: Opportunity and Challenges
ISSN: 2329-6674

Enzyme Engineering
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Review Article

An Overview of P450 Enzymes: Opportunity and Challenges in Industrial Applications

Sandra Notonier, Meyers Alexander and Lahiru N Jayakody*

National Bioenergy Center, National Renewable Energy Lab, 15013 Denver West Parkway, Golden CO 80401, USA

*Corresponding Author:
Lahiru N Jayakody
National Bioenergy Center
National Renewable Energy Lab
15013 Denver West Parkway, Golden CO 80401, USA
Tel: 3033847696
E-mail: [email protected]

Received date: September 13, 2016; Accepted date: October 20, 2016; Published date: October 23, 2016

Citation: Notonier S, Alexander M, Jayakody LN (2016) An Overview of P450 Enzymes: Opportunity and Challenges in Industrial Applications. Enz Eng 5:152. doi:10.4172/2329-6674.1000152

Copyright: © 2016 Notonier S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Cytochrome P450 enzymes (P450s) containing a heme-iron center, are biocatalysts from all kingdoms, involvedin a large variety of reactions. Their potential in catalyzing a broad range of substrates makes perfect candidates for biotechnology applications and the production of high-value compounds. Biocatalytic reactions performed by P450s have a great interest in the pharmaceutical industry, fine chemicals, cosmetics, and for bioremediation procedures. However, the complex nature of this protein is still a major hurdle in the prospect of using their promising ability for expanding the number of industrial applications. Multiple approaches of protein engineering are currently conducted to improve activity, stability and/or substrate specificity for a given reaction. Furthermore, in combination with the appropriate biocatalyst, a suitable bioengineering process is a key step in the implementation of P450s at the industrial scale.


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