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ISSN: 2157-7013

Journal of Cell Science & Therapy
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Review Article

An Overview of the Parameters for Recombinant Protein Expression in Escherichia coli

Bilgimol C Joseph1, Suthakaran Pichaimuthu1,2, Sankaranarayanan Srimeenakshi3, Musti Murthy1, Kalimuthu Selvakumar2, Ganesan M1,2 and Sadananda Rao Manjunath1,2*
1Micro Therapeutic Research Labs Pvt Ltd., Chennai, Tamilnadu, India
2KMS Health Centre Pvt Ltd., Chennai, Tamilnadu, India
3National Institute of Technology Rourkela, Rourkela, Odisha, India
Corresponding Author : Sadananda Rao Manjunath
Micro Therapeutic Research Labs Pvt Ltd
Chennai, Tamilnadu
India and KMS Health Centre Pvt Ltd
Chennai, Tamilnadu, India
E-mail: [email protected];
Received: June 13, 2015; Accepted: August 26, 2015; Published: August 29, 2015
Citation: Joseph BC, Pichaimuthu S, Srimeenakshi S, Murthy M, Selvakumar K, et al. (2015) An Overview of the Parameters for Recombinant Protein Expression in Escherichia Coli. J Cell Sci Ther 6:221. doi:10.4172/2157-7013.1000221
Copyright: © 2015 Joseph BC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Escherichia coli, is one of the most widely preferred organism for the production of recombinant protein. Most of the FDA approved therapeutic proteins are produced in E. coli. The well-established cell factory of E. coli makes it a perfect heterologous system of choice for the production of recombinant proteins. In recent years, several advances have been taken place for modifying these cell factories for easy production of therapeutic proteins with utmost precision. Several molecular tools and protocols are available in hand for the high level protein production in heterologous expression system. Adapting the best strategy for producing recombinant proteins in E. coli can be obtained using several approaches. Combination of strategies will work well to enhance the expression and stability of produced protein. In this review we try to collate different strategies and approaches that can enhance the production as well as the stability of proteins expressed in E. coli.

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