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ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

An Unusual Case of Grave’s Disease with Primary Sclerosing Cholangitis (PSC)

Abdul-Rahman Mashi1* and Naji J Al-Johani2

1Department of Internal Medicine, King Fahad Medical City, Saudi Arabia

2Endocrine and Metabolic Center, King Fahad Medical City, Saudi Arabia

*Corresponding Author:
Abdul-Rahman Mashi
Department of Internal Medicine
King Fahad Medical City, Saudi Arabia
Tel: +966112889999
E-mail: [email protected]

Received Date: December 03, 2016; Accepted Date: January 22, 2017; Published Date: January 27, 2017

Citation: Mashi AR, Al-Johani NJ (2017) An Unusual Case of Grave’s Disease with Primary Sclerosing Cholangitis (PSC). J Clin Case Rep 7: 916. doi: 10.4172/2165-7920.1000916

Copyright: © 2017 Mashi AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Grave’s disease is an autoimmune thyroid disease with multi-system involvement. It’s manifestations are diverse, including liver function abnormalities and association with other autoimmune disease. The objective of this report is to present an unusual case of Grave’s disease with PSC. This is a 28-year-old woman that present with cholestatic jaundice along with signs and symptoms of thyrotoxicosis. She diagnosed to have Grave’s disease with PSC. Despite an initial high bilirubin, treatment with antithyroid agents in addition to Ursodeoxycholic acid led to marked improvement in her clinical status and bilirubin level. The proposed mechanisms underlying the association of Grave’s disease with PSC are discussed and the literature on similar cases is highlighted. Both Grave’s disease and PSC have been shown to be associated with other autoimmune mediated diseases. This case report shows an association between Grave’s disease and PSC whether due to an underlying immune-genetic predisposition or coincidence. Further studies are needed to investigate this association.

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