alexa
Reach Us 44-1522-440391
An Unusual Progression of Follicular Lymphoma Mimicking T-Cell and Histiocyte-Rich Large B-Cell Lymphoma | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

An Unusual Progression of Follicular Lymphoma Mimicking T-Cell and Histiocyte-Rich Large B-Cell Lymphoma

Ashwini Nargund1,2, Steven J. Eastep3, Roger A. Warnke1 and Yasodha Natkunam1*

1Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

2Department of Pathology, St John’s Medical College and Hospital, Bangalore, India

3St. Luke’s Hospital, Duluth, Minnesota, USA

*Corresponding Author:
Yasodha Natkunam
Department of Pathology
L235, Stanford University School of Medicine
300 Pasteur Drive, Stanford, CA 94305-5324, USA
Tel: (650) 725-9354
Fax: (650) 725-7409
E-mail: [email protected]

Received Date: October 13, 2014; Accepted Date: November 01, 2014; Published Date: November 03, 2014

Citation: Nargund A, Eastep SJ, Warnke RA, Natkunam Y (2014) An Unusual Progression of Follicular Lymphoma Mimicking T-Cell and Histiocyte-Rich Large B-Cell Lymphoma . J Cytol Histol 5:289. doi: 10.4172/2157-7099.1000289

Abstract

A significant proportion of follicular lymphoma transform to a higher-grade lymphoma, most commonly, diffuse large B-cell lymphoma. This histologic transformation usually shows diffuse sheets of large cells; however, variant morphologic patterns are also known to occur. We report a case of a 70-year old woman who presented with an unusual large cell transformation of follicular lymphoma with a T-cell and histiocyte-rich background and limited foci of confluent large B-cells. The atypical growth pattern in the excised lymph node led to a broad differential diagnosis that not only included diffuse large B-cell lymphoma but also T-cell lymphoma and nodular lymphocyte predominant Hodgkin lymphoma. Ancillary studies confirmed a neoplastic and clonal B-cell process and immunochemotherapy was initiated. This case illustrates the need for recognition of variant morphologic patterns in large cell transformation of follicular lymphoma for appropriate classification and clinical management.

Keywords

Top