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ISSN: 1745-7580

Immunome Research
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Research Article

An update on Dendritic Cell-Based Cancer Immunotherapy

Shimodaira S1*, Hirabayashi K1, Koya T1, Higuchi Y1, Yanagisawa R1, Okamoto M2 and Koido S3

1Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Nagano 390-8621, Japan

2Department of Advanced Immunotherapeutics, Kitasato University School of Pharmacy, Minato-ku 108-8641, Tokyo, Japan

3Department of Gastroenterology and Hepatology, the Jikei University School of Medicine, Kashiwa, Chiba 277-8567, Japan

Corresponding Author:
Shigetaka Shimodaira
Center for Advanced Cell Therapy
Shinshu University Hospital
Matsumoto, Nagano 390-8621, Japan
Tel: +81-263-37-3580
FAX: +81-263-37-3027
E-mail: [email protected]

Received date: January 06, 2016; Accepted date: March 09, 2016; Published date: February 15, 2016

Citation: Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Yanagisawa R, et al. (2016) An update on Dendritic Cell-Based Cancer Immunotherapy. Immunome Res 12:106. doi:10.4172/1745-7580.10000106

Copyright: © 2016 Shimodaira S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although treating advanced cancers that affect organs with distant metastasis remains challenging, the pace of recent advances has accelerated; these advances have particularly focused on the inhibitors of key immune potentiates. Research on therapeutic vaccination involving active dendritic cell (DC)-based immunotherapy is also being performed for the induction of an effi cient immune response against cancer-associated antigens by the acquired immune system. Cancer vaccines prepared with autologous monocyte-derived mature DCs have been generated using granulocyte–macrophage colony-stimulating factor and interleukin-4, which are principally attributed to the presence of tumor-associated antigens. Wilms’ tumor 1 (WT1) is an attractive target antigen that is widely detected in many cancers. DC-based immunotherapy targeting WT1 may elicit a strong therapeutic response to cancers. DC vaccines primed with HLA class I/II-restricted WT1 peptides (WT1-DC) are a feasible option for patients with advanced cancers. Immune response monitoring using tetramer analysis and/or enzyme-linked immunosorbent spot assay has been applied to determine the effi cacy of WT1-DC. The inhibition of immune suppressors and acceleration of anti-cancer immunity with WT1-DC may comprise a promising future therapeutic strategy for treating advanced cancers.

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