alexa Anal Cancer Screening for Diagnosis and Treatment of Anal Squamous Intaepithelial Lesions in HIV-positive MSM Patients
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Anal Cancer Screening for Diagnosis and Treatment of Anal Squamous Intaepithelial Lesions in HIV-positive MSM Patients

Mercuri A1, Sfara C1, Cavazzoni E2,4*, Del Sordo R3, Marino E2, Graziosi L2, Baldelli F1 and Francisci D1

1 Clinic of Infectious Diseases, University of Perugia, Italy

2 Clinic of General and Emergency Surgery, University of Perugia, Italy

3 Institute of Pathological Anatomy, University of Perugia, Italy

4 Department of Surgery, University of Perugia, Dottori Perugia Italy

*Corresponding Author:
Emanuel Cavazzoni
Department of Surgery
University of Perugia
Dottori Perugia Italy
Tel: +393933567040
E-mail: [email protected]

Received Date: November 14, 2013; Accepted Date: December 16, 2013; Published Date: December 20, 2013

Citation: Mercuri A, Sfara C, Cavazzoni E, Del Sordo R, Marino E, et al. (2013) Anal Cancer Screening for Diagnosis and Treatment of Anal Squamous Intaepithelial Lesions in HIV-positive MSM Patients. J AIDS Clin Res 5:271. doi:10.4172/2155-6113.1000271

Copyright: © 2013 Mercuri A, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Incidence of anal cancer is increasing in HIV+ patients. We have structured a control program in HIV-positive MSM with anal PAP-test and HPV genotyping based on the outcome of anal cytology. Follow-up has been listed according to the HPV genotype infection. Traditional anoscopy and histological exam (also if no visible mucosal lesions, by quadrant random biopsies) was offered to every patient with every abnormal cytology for detection and treatment of squamous anal lesions. Of 87 subjects enrolled, 22 patients (25%) had pathological cytology and 65 patients had PAP-smear negative. No differences in demographic and immuo-virological profile were found in the two groups. Precancerous anal lesions and cancer (1 AIN2, 2 AIN3 and 1 SCC) were treated surgically if advanced otherwise with imiquimod cream into the anal canal; squamous cell carcinoma was referred to oncologist. High prevalence of HPV infection and anal intraepithelial neoplasia are important risk factors for anal cancer: anal precancerous lesions can be detected early and treated in at-risk populations


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