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ISSN: 1948-5956

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  • Research Article   
  • J Cancer Sci Ther/Vol.10.2 019(2018),
  • DOI: 10.4172/1948-5956.1000510

Analysis of A Single Para-Aortic Lymph Node Metastasis in Endometrial Cancer

Motoki Matsuura*, Akimasa Takahashi, Hidetaka Nomura, Maki Matoda, Sanshiro Okamoto, Hiroyuki Kanao, Kohei Omatsu, Kazuyoshi Kato, Kuniko Utsugi and Nobuhiro Takeshima
Department of Gynecologic Oncology, Cancer Institute Hospital, , Tokyo, Japan
*Corresponding Author : Motoki Matsuura, Department of Gynecologic Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan, Tel: 8133520 0111, Fax: 81335700343, Email: [email protected]

Received Date: Feb 05, 2018 / Accepted Date: Feb 12, 2018 / Published Date: Feb 14, 2018

Abstract

Objective: To determine the indication for lymph node dissection in patients with endometrial cancer, we investigated the incidence and distribution of single metastatic lymph nodes in patients who underwent systematic pelvic and para-aortic lymph node dissection.
Methods: This study involved 910 patients with endometrial cancer who were treated at the Cancer Institute Hospital, Japan, between January 1994 and December 2015. All patients underwent an open hysterectomy with bilateral salpingo-oophorectomy and pelvic and para-aortic lymph nodes dissection.
Results: Lymph node metastasis was observed in 199 patients (21.9%), 45 (5%) of whom had single lymph node metastasis. Single lymph node metastasis accounted for 22.6% of all metastatic cases. Myometrial invasion >50% was observed in 30 patients, whereas 15 patients had <50% myometrial invasion. When mapping single lymph node metastatic sites, the para-aortic area had a frequency of 31.1% (14 cases). The distribution of single metastatic lymph nodes spanned a wide area between the pelvic and para-aortic regions. Considering single metastatic nodes and myometrial invasion, 8 patients (53.3%) who had myometrial invasion <50% had a single metastatic node in the para-aortic region. Four of 9 patients (45%) considered low-risk (endometrioid Grade 1-2, invasion depth <50%, no lymphovascular space invasion) showed metastasis to the para-aortic areas.
Conclusion: Single metastatic lymph nodes were widely distributed between the pelvic and para-aortic regions, suggesting that detection of a sentinel lymph node in patients with endometrial cancer could be problematic.

Keywords: Endometrial cancer; Single para-aortic metastasis; Sentinel lymph node

Citation: Matsuura M, Takahashi A, Nomura H, Matoda M, Okamoto S, et al. (2018) Analysis of A Single Para-Aortic Lymph Node Metastasis in Endometrial Cancer. J Cancer Sci Ther 10: 019-021. Doi: 10.4172/1948-5956.1000510

Copyright: © 2018 Matsuura M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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