alexa Analysis of Aldosterone Synthase Gene Promoter (- 344 C >T) Polymorphism in Indian Diabetic Nephropathy Patients | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Analysis of Aldosterone Synthase Gene Promoter (- 344 C >T) Polymorphism in Indian Diabetic Nephropathy Patients

Pulakes Purkait1, Raychodhury P2, Bandhyopadhya S3, Naidu JM4 and Sarkar BN5*

1Anthropological Survey of India, WRC, Rajasthan, India

2Calcutta Medical College and Hospital, Kolkata, India

3BP Poddar Hospital and Research LTD, Kolkata, India

4VNR Vignana Jyothi Institute of Engineering and Technology, Andhra Pradesh, India

5Anthropological Survey of India, Kolkata, India

*Corresponding Author:
Sarkar BN
Anthropological Survey of India
27 Jawaharlal Nehru Road
Kolkata-700016, India
E-mail: [email protected]

Received date: April 20, 2013; Accepted date: June 16, 2013; Published date: June 20, 2013

Citation: Purkait P, Raychodhury P, Bandhyopadhya S, Naidu JM, Sarkar BN (2013) Analysis of Aldosterone Synthase Gene Promoter (- 344 C >T) Polymorphism in Indian Diabetic Nephropathy Patients. J Diabetes Metab 4:271. doi: 10.4172/2155-6156.1000271

Copyright: © 2013 Purkait P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: the aim of the present study is to evaluate the association between CYP11B2gene and type 2 diabetic nephropathy patients in Indian population.

Result: There was a significant difference in age, cholesterol, triglycerides, HDL, creatinine, BUN, Uric acid, total protein, Albumin, SBP, DBP variables except LDL Cholesterol among the study groups. The frequencies of CYP11B2 gene CC, CT, TT genotypes among the T2DNH are 16.67 %, 51.19 %, 32.14 %; in T2DM patient 10.66 %, 52.46 %, 36.88 % and 16.95%, 38.14%, 44.91% in controls respectively and we could not observe significant differences in both genotype (x2=7.289, p=0.121) and allele frequency (X2=1.82, p=0.403) of the CYP11B2 gene (-344 T>C) polymorphism between T2DNH, T2DM patients and Controls subjects.

Conclusion: Our findings do not support the hypothesis that CYP11B2 polymorphism is associated with prevalence of Type 2 diabetic nephropathy patients in Indian populations.

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