alexa Analysis of Binding Properties of Phosphoinositide 3-kinase Through <em>In silico</em> Molecular Docking
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Analysis of Binding Properties of Phosphoinositide 3-kinase Through In silico Molecular Docking

P. Daisy*, R. Sasikala, A. Ambika

Bioinformatics centre (BIF), Department of Biotechnology & Bioinformatics, Holy Cross College, Tepakulam, Tiruchirapalli-620002, India

*Corresponding Author:
Dr. P. Daisy
Co-coordinator, Bioinformatics centre (BIF)
Department of Biotechnology & Bioinformatics
Holy Cross College, Tepakulam,Tiruchirapalli-620002
Tel: 0431-2700637
Fax: 0431-2713312
E-mail: [email protected]

Received Date: May 12, 2009; Accepted Date: June 18, 2009; Published Date: June 18, 2009

Citation: Daisy P, Sasikala R, Ambika A (2009) Analysis of Binding Properties of Phosphoinositide 3-kinase Through In silico Molecular Docking. J Proteomics Bioinform 2: 274-284. doi: 10.4172/jpb.1000086

Copyright: © 2009 Daisy P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Phosphoinositide 3-kinases (PI3-kinases) are increasingly considered to have a key role in intracellular signal transduction in health and disease. Particularly the enzymes plays vital role in wide range of cancer such as breast, ovarian, myeloid leukemia, prostate, Small Cell Lung cancer (SCLC) etc., Compounds such as Wortmannin, LYS2002 are the inhibitors of PI3-kinases but these compounds shown adverse side effects . Hence five natural flavanoids having inhibitory effects on PI3-kinase namely Andrographolide, Kaempferol, Luteolin, Quercetin and Gingerol were taken for in silico prediction of binding affinities of the protein PI3- kinase. Our reports can be used to develop new inhibitors with better binding affinities towards the protein PI3-kinase protein. For the binding analysis the catalytic subunit of the protein PI-3 Kinase p110? was taken for the study as it considered being a potential target in cancer treatment.

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