Analysis of Botulinum Neurotoxin Detection by Mass Spectrometry in Forensic Samples
Harvey J M Hou*
Department of Physical Sciences, Alabama State University, USA
- *Corresponding Author:
- Harvey J M Hou
Department of Physical Sciences, Alabama State University
915 South Jackson Street, Montgomery, Alabama 36104, USA
E-mail: [email protected]
Received date: June 11, 2013; Accepted date: July 10, 2013; Published date: July 23, 2013
Citation: Hou HJM (2013) Analysis of Botulinum Neurotoxin Detection by Mass Spectrometry in Forensic Samples. J Forensic Res 4:185. doi:10.4172/2157-7145.1000185
Copyright: © 2013 Hou HJM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Microbial forensics is emerged as a new interdisciplinary field and focuses on the characterization, analysis and interpretation of evidence from the scene of bioterrorism or biocrimes. Mass spectrometry is one of the key techniques in the identification of botulinum neurotoxins, which are among the top six species in the list of bioagents. In this review, I overview the current understanding of structure and function of botulinum neurotoxins, introduce the detection and identification of botulinum neurotoxins, and discuss the progress and the possible strategies of “botulinum neurotoxins signatures” in microbial forensics. The “botulinum neurotoxins signatures” may be obtained using bioanalytical and biophysical methodologies, especially mass spectral proteomics and may provide specific information in detecting and identifying botulinum neurotoxins to combat bioterrorism and biocrimes.