alexa Analysis of Chromosomal Aberrations in PBL of Chrome Tanning Industrial Workers
ISSN: 2161-0940

Anatomy & Physiology: Current Research
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Review Article

Analysis of Chromosomal Aberrations in PBL of Chrome Tanning Industrial Workers

Anusha C Pawar1, S Jithender Kumar Naik1, M V Raghavendern Rao2*, K Sireesha V Mangesh1 and S Anitha Kumari1

1Occupational Health and Toxicology Lab, Department of Zoology, University College of Sciences, Osmania University, India

2Department of Medical Microbiology & Parasitology, Avalon University School of Medicine, Sta.Rosaweg, Williemstad, Curacao, Netherlands

*Corresponding Author:
M V Raghavendern Rao
Professor of Medical Microbiology & Parasitology
Avalon University School of Medicine, Sta.Rosaweg 122-124. Williemstad
Curacao, Netherlands Antilles
Tel: 59997888008
E-mail: [email protected]

Received date: December 19, 2015 Accepted date: February 23, 2016 Published date: February 26, 2016

Citation: Pawar AC, Naik SJK, Rao MVR, Mangesh KSV, Kumari SA (2016) Analysis of Chromosomal Aberrations in PBL of Chrome Tanning Industrial Workers . Anat Physiol 6:205. doi:10.4172/2161-0940.1000205

Copyright: © 2016 Pawar AC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In order to monitor the geno-toxic effects of chromium compound, 160 chrome tanning industrial workers (80 each of smoker and non-smoker) were selected from a leather tanning industry to perform the cytogenetic protocol of chromosomal aberrations in the peripheral blood lymphocytes. The workers were further classified into two groups on the basis of their personnel habit (Smoker and Non-Smokers) and on the duration of their employment (1-5, 6-10 and 11-15 years). Even 120 individuals (62 smokers and 58 non-smokers) were also selected as controls for the purpose of comparison. A statistically significant increased frequency of total chromosomal aberrations was observed in the chrome tannery workers (6.20 ± 0.12) as against the control (1.61 ± 0.09). The increased frequencies of aberrations were duration dependent. Even higher incidence of chromosome aberrations was reported among the smoker group of both control and exposed workers. The results clearly establish the mutagenic nature of the chromium compound in human beings.


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