alexa Analysis of Functional Dissociations between Best Corrected Visual Acuity and Microperimetric Parameters in Neovascular Age-Related Macular Degeneration Patients Underwent to Three Monthly Ranibizumab Injections | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

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Research Article

Analysis of Functional Dissociations between Best Corrected Visual Acuity and Microperimetric Parameters in Neovascular Age-Related Macular Degeneration Patients Underwent to Three Monthly Ranibizumab Injections

Stefano Lazzeri1,2*, Paolo Piaggi3,4, Maria Cristina Parravano2, Guido Ripandelli2, Maria Sole Sartini1, Fabio Scarinci2, Gaetano Cupo2, Gianluca Guidi1, Andrea Cacciamani1, Marco Nardi1, Piergiorgio Neri5, Monica Varano2 and Michele Figus1
1Department of Neuroscience, Ophthalmology, University of Pisa, Pisa, Italy
2Bietti Foundation, IRCCS, Rome, Italy
3Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
4Department of Energy and Systems Engineering, University of Pisa, Pisa, Italy
5Head of Ocular Immunology Unit, Ophthalmology, University of Ancona, Ancona, Italy
Corresponding Author : Stefano Lazzeri, MD
Department of Neuroscience
Ophthalmology, University of Pisa
Via Paradisa 2, Pisa 56100, Italy
Tel: +39 050997634
E-mail: [email protected]
Received July 25, 2013; Accepted August 29, 2013; Published August 31, 2013
Citation: Lazzeri S, Piaggi P, Parravano MC, Ripandelli G, Sartini MS, et al. (2013) Analysis of Functional Dissociations between Best Corrected Visual Acuity and Microperimetric Parameters in Neovascular Age-Related Macular Degeneration Patients Underwent to Three Monthly Ranibizumab Injections. J Clin Exp Ophthalmol 4:293. doi:10.4172/2155-9570.1000293
Copyright: © 2013 Lazzeri S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: To analyze the sensitivity of best corrected visual acuity and microperimetry to detect significant visual changes after 3 intravitreal ranibizumab in exudative age-related macular degeneration.

Design: Prospective, open-label study.

Participants: 50 eyes of 50 naïve patients affected by neovascular age-related macular degeneration were enrolled.

Methods: Enrolled patients underwent to a loading phase of 3 monthly intravitreal injections of ranibizumab. Best-corrected visual acuity was investigated with the ETDRS chart at 4 m. Central retinal sensitivity was tested with microperimetry using a Goldmann III stimulus to 33 points over the 12° central of the macula with a 4-2 double staircase strategy.

Main outcome measures: Comparison of changes in mean 4° central retinal sensitivity and best-corrected visual acuity in “BCVA relatively stable patients” (defined as change ≤ ± 4 ETDRS letters after treatment). Analysis of a possible relationship between changes in best-corrected visual acuity and 4° central retinal sensitivity in “mean 4° central retinal sensitivity relatively stable patients” (defined as change in mean retinal sensitivity ≤ ± 2dB)

Results: Mean best-corrected visual acuity improved of 5.90 ± 11.29 ETDRS letters (P=0.0006). Total mean retinal sensitivity improved +1.59 ± 2.12 dB (P<0.0001), while in the 4° central retinal area the increase was +1.36 ± 3.45 dB (P=0.0078). 38% of patients (19 eyes) were considered as “BCVA relatively stable patients”. In this subgroup, Pearson’s correlation analysis showed a direct correlation between changes observed with both methods (r = 0.71; P = 0.002). 48% of patients (24 eyes) were considered as “Mean 4° central retinal sensitivity relatively stable patients”. In this subgroup, Pearson’s correlation analysis didn’t show a relationship between changes observed with both methods (r = 0.11; P = 0.56).

Conclusions: Microperimetry central retinal sensitivity seems to be an important to complete the functional evaluation in patients with wet age-related macular degeneration after 3 intravitreal ranibizumab.

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