alexa Analysis of Phosphorylated Neurofilament H Levels in a Low Birth Weight Infant with Posthemorrhagic Hydrocephalus: A Case Report
ISSN: 2161-0665

Pediatrics & Therapeutics
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Case Report

Analysis of Phosphorylated Neurofilament H Levels in a Low Birth Weight Infant with Posthemorrhagic Hydrocephalus: A Case Report

Mitsuo Motobayashi1, Yuji Inaba1*, Mai Kusakari1, Taemi Niimi1, Naoko Shiba1, Kanae Hirabayashi1, Takafumi Nishimura1, Takefumi Ishida1, Masatomo Kitamura1, Atsushi Baba1, Yoshihiko Katsuyama2 and Kenichi Koike1

1Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan

2Department of Pharmacy, Shinshu University School of Medicine, Matsumoto, Japan

*Corresponding Author:
Yuji Inaba
Department of Pediatrics
Shinshu University School of Medicine
3-1-1 Asahi, Matsumoto 390-8621, Japan
Tel: +81-263-37-2642
Fax: +81-263-37-3089
E-mail: [email protected]

Received Date: September 26, 2013; Accepted Date: January 23, 2014; Published Date: January 27, 2014

Citation: Motobayashi M, Inaba Y, Kusakari M, Niimi T, Shiba N, et al. (2014) Analysis of Phosphorylated Neurofilament H Levels in a Low Birth Weight Infant with Posthemorrhagic Hydrocephalus: A Case Report. Pediat Therapeut 4:189. doi:10.4172/2161-0665.1000189

Copyright: © 2014 Motobayashi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Recent studies have reported on the phosphorylated forms of neurofilament H (pNf-H) in patients with brain damage, but not in preterm infants. This report presents the serial measurements of serum pNf-H from an Extremely Low Birth Weight Infant (ELBWI) who had neonatal seizures, Brainstem Release Phenomena (BRP), and Posthemorrhagic Hydrocephalus (PHHC). All pNf-H values in this patient (1.63- 3.92 ng/ml) were higher than those in age-matched control infants (n=19; 0.43 ± 0.51 ng/ml, mean ± SD) and displayed two peaks: the first on day 3 after birth was considered to be caused by birth asphyxia, while the second gradual peak was believed to correspond to the progression of the PHHC that caused BRP. Our results demonstrated that measurements of serum pNf-H were useful even in ELBWIs because they could closely reflect such forms of brain damage as PHHC and BRP.


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