Analysis of Risk Factors and Prognosis for Ovarian Metastasis in Patients with Endometrial CarcinomaQun Zhao and Yumei Wu*
Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
- Corresponding Author:
- Wu Yumei
Department of Gynecological Oncology
Beijing Obstetrics and Gynecology Hospital
Capital Medical University, Beijing, China
E-mail: [email protected]
Received Date: May 26, 2013; Accepted Date: June 23, 2013; Published Date: June 27, 2013
Citation: Zhao Q, Wu Y (2013) Analysis of Risk Factors and Prognosis for Ovarian Metastasis in Patients with Endometrial Carcinoma. Gynecol Obstet 3:152. doi: 10.4172/2161-0932.1000152
Copyright: © 2013 Zhao Q, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To investigate the risk factors and prognosis for ovarian metastasis in patients with endometrial carcinoma.
Methods of study: Seven hundred sixty-four cases of endometrial carcinoma treated in Beijing Obstetrics and Gynecology Hospital (BOGH) during the period between September, 1970 and August, 2011 were retrospectively analyzed. All the cases had complete surgical and pathological records.
Results: Among 764 cases of endometrial carcinoma analyzed, 23 (3.01%) cases had ovarian metastasis. Univariate analyses found that the depth of muscular invasion, peritoneal lavage cytology, histological grading, cervical migration, parametrial metastasis, fallopian tube metastasis and lymph node metastasis were significantly different between two groups with (n=23) or without (n=741) ovarian metastasis. Multivariate Logistic regression analysis revealed that factors predictive of ovarian metastasis included peritoneal lavage cytology and the depth of muscular invasion. Endometrial carcinoma patients with ovarian metastasis had poorer five-year survival rate and higher recurrent rate than those without ovarian metastasis.
Conclusion: Parametrial metastasis, positive tumor cells in peritoneal lavage and deep muscular invasion are independent risk factors for ovarian metastasis of endometrial carcinoma. Endometrial carcinoma patients with ovarian metastasis are more poorly prognostic.