alexa Analysis of Synapsin I and II mRNAs and Proteins During Murine Development
ISSN: 2168-9547

Molecular Biology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Analysis of Synapsin I and II mRNAs and Proteins During Murine Development

Michael RR*

Department of Biology, University of Puerto Rico at Cayey, Puerto Rico

*Corresponding Author:
Michael RR
Department of Biology
University of Puerto Rico at Cayey
Puerto Rico
Tel: (787)-738-7473
E-mail: [email protected]

Received date: June 12, 2017; Accepted date: June 23, 2017; Published date: June 30, 2017

Citation: Michael RR (2017) Analysis of Synapsin I and II mRNAs and Proteins During Murine Development. Mol Biol 6:192. doi:10.4172/2168-9547.1000192

Copyright: © 2017 Michael RR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The synapsins are a family of neuronal phosphoproteins that have been previously shown to play an important regulatory role in the release of neurotransmitter from the presynaptic terminal and in the process of synaptogenesis. The mechanisms that regulate the formation of synaptic terminals are a central process in determining the specificity of synaptogenesis and the development of the nervous system. Proteins involved in neurotransmitter release and the control of this release process (specifically synaptic vesicle proteins) have been implicated as being important for synaptogenesis. To determine whether synapsin is expressed at times during mouse development when synaptogenic activity is high, we examined the time course of synapsin I and II mRNA and protein expression in embryonic and postnatal mice using Northern blot and Western blot analyses. Quantification of these blot analyses demonstrated that synapsin RNA and protein can be detected as early as 13.5 days of mouse embryogenesis and that expression of five of the six isoforms of synapsin increase throughout embryonic and postnataldevelopment reaching characteristic high levels by adulthood. This early expression pattern suggests an important role for the synapsins in the development of the mammalian nervous system.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version