Reach Us +44-1625-708989
Analysis of the Difference in the Pressure-Natriuresis Relationship Based on the Class of Medication Using Spot Urine Tests in Hypertensive Patients | OMICS International | Abstract
ISSN: 2167-1095

Journal of Hypertension: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Analysis of the Difference in the Pressure-Natriuresis Relationship Based on the Class of Medication Using Spot Urine Tests in Hypertensive Patients

ShiroHoshida*, Takafumi Nakagawa, Yukinori Shinoda, Hirooki Inui and Tetsuya Watanabe

Division of Cardiovascular Medicine, Yao Municipal Hospital, 1-3-1 Ryuge-cho, Yao, Osaka 581-0069, Japan

*Corresponding Author:
Shiro Hoshida
Vice President, Division of Cardiovascular Medicine
Yao Municipal Hospital, 1-3-1 Ryuge-cho
Yao Osaka 581-0069, Japan
Tel: 81729220881
Fax: 81729244820
E-mail: [email protected]

Received Date: May 25, 2014; Accepted Date: June 23, 2014; Published Date: June 28, 2014

Citation: Hoshida S, Nakagawa T, Shinoda Y, Inui H, Watanabe T (2014) Analysis of the Difference in the Pressure-Natriuresis Relationship Based on the Class of Medication Using Spot Urine Tests in Hypertensive Patients. J Hypertens 3:154. doi:10.4172/2167-1095.1000154

Copyright: © 2014 Hoshida S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: We estimated the daily sodium intake using a spot urine method in hypertensive patients, and investigated the differences in the pressure-natriuresis relationship depending on the type of medications and the involvement of renal function in this relationship.

Methods: This study included 356 spot urine samples of hypertensive patients at our cardiology outpatient clinic. Daily sodium intake was estimated by the spot urine tests at the time of study enrolment. We examined the difference in the relationships among estimated daily sodium intake, mean blood pressure (mBP), and estimated glomerular filtration rate (eGFR) with each medication.

Results: In multivariate analysis, the eGFR and mBP were significantly associated with estimated daily sodium intake. The slope of the pressure-natriuresis relationship was steeper in patients treated with renin-angiotensin system inhibitors (RAS-I) plus diuretics, and lower in patients treated with RAS-I plus calcium-channel blockers (CCB) than in those treated with CCB or who were not treated. eGFR was higher in patients with higher daily sodium intake than in those with lower daily sodium intake in association with higher mBP, except for patients treated with CCB alone.

Conclusions: Estimated daily sodium intake in hypertensive patients was positively correlated with eGFR and mBP. The slope of the pressure-natriuresis relationship curve was different depending on the class of medication. In hypertensive patients with higher sodium intake, the relationship between mBP and eGFR may be important when selecting the type of medication.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version