alexa Analysis of the Impacts of Environmental Pollution of P
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Analysis of the Impacts of Environmental Pollution of Pesticides on Oxidative Stress Profile in Liver and Kidney: A Case of Raid® in Wistar Rat

Achudume AC*
Institute of Ecology and Environmental Studies, Obafemi Awolowo University, Nigeria
Corresponding Author : Achudume AC
Institute of Ecology and Environmental Studies
Obafemi Awolowo University, Nigeria
E-mail: [email protected]
Received January 10, 2012; Accepted February 14, 2012; Published February 16, 2012
Citation: Achudume AC (2012) Analysis of the Impacts of Environmental Pollution of Pesticides on Oxidative Stress Profile in Liver and Kidney: A Case of Raid® in Wistar Rat. J Environment Analytic Toxicol 2:124. doi: 10.4172/2161-0525.1000124
Copyright: © 2013 Jung YG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The widespread use of pesticides has numerous pathological consequences including agents which generate oxidative stress. Analysis of impacts of pesticides and oxidative stress provide available evidence that suggests changes that play a key role in various conditions which limit the human life span. Ingestion of insecticide Raid® was administered to wistar rats for 30 and 60 days and various target organs of rats were examined for oxidative stress profile. Results showed that all the parameters either in erythrocyte or the organs compared negatively with the control groups (P<.05). The results indicated that catalase, superoxidedimutase (SOD), glutatathione reductase (Gr), and glutathione (GSH) levels significantly decreased in rats treated with insecticide Raid® alone compared with the liver and kidney. Besides, raid-induced oxidative damage caused a significant increase in malondialdehyde (MDA) levels of the liver and kidney tissues. Even more disturbing is the fact that pesticide is typically associated with cellular dysfunction as discussed.

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