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Analysis of Total Urine Proteins: Towards a Non-Invasive Approach for Diagnosis of Visceral Leishmaniasis | OMICS International | Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Analysis of Total Urine Proteins: Towards a Non-Invasive Approach for Diagnosis of Visceral Leishmaniasis

Om Prakash Singh and Shyam Sundar*

Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

*Corresponding Author:
Prof. Shyam Sundar
Department of Medicine
Institute of Medical Sciences
Banaras Hindu University
Varanasi-221 005, UP, India
Tel: +915422369632
E-mail: [email protected]

Received date: July 22, 2012; Accepted date: August 24, 2012; Published date: August 27, 2012

Citation: Singh OP, Sundar S (2012) Analysis of Total Urine Proteins: Towards a Non-Invasive Approach for Diagnosis of Visceral Leishmaniasis. J Mol Biomark Diagn 3:131. doi:10.4172/2155-9929.1000131

Copyright: © 2012 Singh OP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Diagnosis of Visceral Leishmaniasis (VL) is a major obstacle in the control of this disease, as demonstration of parasite by splenic or bone-marrow aspiration is almost impossible in the peripheral rural areas because of lack of facilities. In order to identify a non-invasive biomarker for VL, we employed two-dimensional electrophoresis (2D-PAGE) coupled with mass spectrometry through a comparison of urinary proteome. Though, we did not find the biomarker protein for VL, our findings provide some basic insights for future development of non invasive diagnostic tool.

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