Analysis on the Potential Clinical Bio-marks for Decabromodiphenyl Ether ExposureHongmei Wang1, Beidou Xi1, Hongyan Wang1,2, Han Zhang1*, Congli Ma1,3, Yuguo Jiao3 and Yuejiao Zhang4,5
- *Corresponding Author:
- Jinliang Zhang
State Key Laboratory of Environmental Criteria and Risk Assessment
Chinese Research Academy of Environmental Sciences
Chaoyangdistrict, 100012, PRC China
E-mail: [email protected]
Received date: October 20, 2012; Accepted date: Novmeber 15, 2012; Published date: Novmeber 17, 2012
Citation: Wang HM, Xi BD, Wang HY, Zhang JL, Ma CL, et al. (2012) Analysis on the Potential Clinical Bio-marks for Decabromodiphenyl Ether Exposure. J Mol Biomark Diagn 3:137.doi: 10.4172/2155-9929.1000137
Copyright: © 2012 Wang HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Decabromodiphenyl ether (BDE 209) was one of the flame retardants in a variety of commercial and household products. The toxicity of BDE 209 was thought to be associated with neurotoxicity, changes in fetal development, and endocrine disruption etc. Although different toxicology effects of BDE 209 exposure had been reported, the information of BDE 209 on Jurkat cells was still insufficient, and the molecular bio-marks were still unknown. In this research, the gene expression profiling was analyzed. Changes of gene expression induced by BDE 209 could be classified into neurotoxicity, apoptosis and reproductive toxicity. Quantifying microRNA expression levels was verified by real-time PCR. The expression levels of Brain-Derived Neurotrophic Factor (BDNF), Regulating synaptic membrane exocytosis 3 (RIMS3) and dihydropyrimidinase-like 3 (DPYSL3), which were associated with the neurotoxicity and brain development, presented trends of down-regulated. Based on the abundance of gene expression analysis in tissues and cells and taking the possibility of biological samples obtained for the clinical diagnosis into consideration, BDNF, that had been confirmed as one of the key genes in the neurotoxicity, was recommended as one of the main clinical bio-marks in the epidemiology, since it had been found abundant in the blood monocyte.