Analytical Assessment of TNF-Antagonist Early Effects on Psoriasis: In Vivo Real-time Reflectance Confocal Microscopy and Skin Capacitance Mapping
|Piérard GE1*, Hermanns-Lê T2, Piérard-Franchimont C2,3 and Piérard SL4|
|1Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, University of Liège, Belgium|
|2Department of Dermatopathology, Unilab Lg, Liège University Hospital, Liège, Belgium|
|3Department of Dermatology, Regional Hospital of Huy, Belgium|
|4Telecommunications and Imaging Laboratory INTELSIG, Montefiore Institute, University of Liège, Belgium|
|Corresponding Author :||Gérald E Piérard
University of Liège
Laboratory of Skin Bioengineering and Imaging (LABIC)
CHU Sart Tilman, BE-4000 Liège, Belgium
Tel: +32 4 3662408
Fax: +32 4 3662976
E-mail: [email protected]
|Received October 23, 2014; Accepted November 14, 2014; Published November 21, 2014|
|Citation: Piérard GE, Hermanns-Lê T, Piérard-Franchimont C, Piérard SL (2014) Analytical Assessment of TNF-Antagonist Early Effects on Psoriasis: In Vivo Real-time Reflectance Confocal Microscopy and Skin Capacitance Mapping. J Med Diagn Meth 3:165. doi:10.4172/2168-9784.1000165|
|Copyright: © 2014 Piérard GE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Objective: Treatment options for moderate to severe skin psoriasis have considerably progressed over the past decades with the widespread use of targeted biologicals including Tumor Necrosis Factor antagonists (TNFa).
Objective and reliable analytical assessments of the disease course and the treatment efficacy are eagerly awaited.
Methods: To disclose initial therapeutic effects of the adalimumab TNFa in a group of 13 psoriatic patients. The analytical observations relied on two in vivo real-time non-invasive methods, namely Reflectance Confocal Microscopy (RCM) and skin capacitance mapping (SCM). The L* colorimetric assessment of pictures was used for analytical assessments.