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Analytical Model for the Assessment of Efficiency of Stem Cell Transplantation with Suicidal Gene Construct for the Treatment of Leukemia | OMICS International | Abstract
ISSN: 2476-2261

Journal of Oncology Translational Research
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Research Article

Analytical Model for the Assessment of Efficiency of Stem Cell Transplantation with Suicidal Gene Construct for the Treatment of Leukemia

Probir Kumar Dhar1-3, Tarun Kanti Naskar1,3 and Durjoy Majumder1,4*

1Society for Systems Biology and Translational Research, 103, Block–C, Bangur Avenue, Kolkata 700 055, India

2Department of Electronics and Communication Engineering, Bengal College of Engineering and Technology, Sahid Sukumar Banerjee Sarani, Bidhannagar, Durgapur 713212, Burdwan, West Bengal, India

3Department of Mechanical Engineering, Jadavpur University, 188 Raja S. C. Mallick Road, Kolkata 700032, India

4Department of Physiology, West Bengal State University, Berunanpukuria, Malikapur, Barasat, Kolkata 700126, India

*Corresponding Author:
Durjoy Majumder
Department of Physiology, West Bengal State University
Berunanpukuria, Malikapur, Barasat, Kolkata 700126
or, Society for Systems Biology & Translational Research
Kolkata 700 055; India
Tel: 033 25241979
E-mail: [email protected] or [email protected]

Received date: September 28, 2015; Accepted date: November 26, 2015; Published date: December 02, 2015

Citation: Dhar PK, Naskar TK, Majumder D (2015) Analytical Model for the Assessment of Efficiency of Stem Cell Transplantation with Suicidal Gene Construct for the Treatment of Leukemia. Oncol Trans Res 1:103. doi:10.4172/jotr.1000103

Copyright: © 2015 Dhar PK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hematopoietic stem cell transplantation is now being the emergent methodology for leukemia treatment. Due to HLA mis-match, there is chance of transplantation related mortality. However, with the increase in HLA mis-match between donor cells and recipient, there is more chance of complete removal of leukemic cells in host (patient). To tackle this, recently stem cells transplantation with suicidal tk-gene construct is being suggested. Due to unavailability of suitable analytical methods this option has limited applications in clinical cases. Present work provides an analytical platform to test the efficacy of this therapeutic procedure.

Keywords

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