Analytical Model for the Assessment of Efficiency of Stem Cell Transplantation with Suicidal Gene Construct for the Treatment of Leukemia
- *Corresponding Author:
- Durjoy Majumder
Department of Physiology, West Bengal State University
Berunanpukuria, Malikapur, Barasat, Kolkata 700126
or, Society for Systems Biology & Translational Research
Kolkata 700 055; India
Tel: 033 25241979
E-mail: [email protected] or [email protected]
Received date: September 28, 2015; Accepted date: November 26, 2015; Published date: December 02, 2015
Citation: Dhar PK, Naskar TK, Majumder D (2015) Analytical Model for the Assessment of Efficiency of Stem Cell Transplantation with Suicidal Gene Construct for the Treatment of Leukemia. Oncol Trans Res 1:103. doi:10.4172/jotr.1000103
Copyright: © 2015 Dhar PK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hematopoietic stem cell transplantation is now being the emergent methodology for leukemia treatment. Due to HLA mis-match, there is chance of transplantation related mortality. However, with the increase in HLA mis-match between donor cells and recipient, there is more chance of complete removal of leukemic cells in host (patient). To tackle this, recently stem cells transplantation with suicidal tk-gene construct is being suggested. Due to unavailability of suitable analytical methods this option has limited applications in clinical cases. Present work provides an analytical platform to test the efficacy of this therapeutic procedure.