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Ancient Origin of Chaperonin Gene Paralogs Involved in Ciliopathies | OMICS International | Abstract
ISSN: 2329-9002

Journal of Phylogenetics & Evolutionary Biology
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Research Article

Ancient Origin of Chaperonin Gene Paralogs Involved in Ciliopathies

Krishanu Mukherjee1 and Luciano Brocchieri2*
1Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32610-3610, USA
2Department of Molecular Genetics and Microbiology and Genetics Institute, University of Florida, Gainesville, FL 32610-3610, USA
Corresponding Author : Luciano Brocchieri
Department of Molecular Genetics and Microbiology and Genetics Institute
University of Florida, Gainesville, FL 32610-3610, USA
Tel: 352-273-8131
Email: [email protected]
Received January 31, 2013; Accepted April 15, 2013; Published April 23, 2013
Citation: Mukherjee K, Brocchieri L (2013) Ancient Origin of Chaperonin Gene Paralogs Involved in Ciliopathies. J Phylogen Evolution Biol 1:107. doi:10.4172/2329-9002.1000107
Copyright: © 2013 Mukherjee K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The Bardet-Biedl Syndrome (BBS) is a human developmental disorder that has been associated with fourteen BBS genes affecting the development of cilia. Three BBS genes are distant relatives of chaperonin proteins, a family of chaperones well known for the protein-folding role of their double-ringed complexes. Chaperonin-like BBS genes were originally thought to be vertebrate-specific, but related genes from different metazoan species have been identified as chaperonin-like BBS genes based on sequence similarity. Our phylogenetic analyses confirmed the classification of these genes in the chaperonin-like BBS gene family, and set the origin of the gene family earlier than the time of separation of Bilateria, Cnidaria, and Placozoa. By extensive searches of chaperonin-like genes in complete genomes representing several eukaryotic lineages, we discovered the presence of chaperonin-like BBS genes also in the genomes of Phytophthora and Pythium, belonging to the group of Oomycetes. This finding suggests that the chaperonin-like BBS gene family had already evolved before the origin of Metazoa, as early in eukaryote evolution as before separation of the lineages of Unikonts and Chromalveolates. The analysis of coding sequences indicated that chaperonin-like BBS proteins have evolved in all lineages under constraining selection. Furthermore, analysis of the predicted structural features suggested that, despite their high rate of divergence, chaperonin-like BBS proteins mostly conservea typical chaperonin-like three-dimensional structure, but question their ability to assemble and function as chaperonin-like double-ringed complexes.

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