alexa Andosan™-An Anti-Allergic and Anti-Inflammat
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Andosan™-An Anti-Allergic and Anti-Inflammatory Ingredient Prepared from Agaricus blazei Mushroom

Geir Hetland1,3*, Stig Palm Therkelsen2, Ivo Nentvich1 and Egil Johnson2,3
1Department of Immunology, Oslo University Hospital, Oslo, Norway
2Department of Gastro-enterological Surgery, Oslo University Hospital, Oslo, Norway
3Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Corresponding Author : Prof. Geir Hetland
Department of Immunology
Oslo University Hospital-Ulleval
Kirkev 166, 0407 Oslo, Norway
Tel: +47 2211 8878
Fax: +47 2211 8500
E-mail: [email protected]
Received: December 15, 2014; Accepted: April 17, 2015; Published: April 24, 2015
Citation: Hetland G, Therkelsen SP, Nentvich I, Johnson e (2015) Andosan™-An Anti-Allergic and Anti-Inflammatory Ingredient Prepared from Agaricus blazei Mushroom. J Clin Cell Immunol 6:320. doi:10.4172/2155-9899.1000320
Copyright: © 2015 Hetland G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Andosan™ is an extract prepared from medicinal Basidiomycetes mushrooms, mainly Agaricus blazei Murill (AbM) (82%), but it also contains Hericeum erinaceus (He) (15%) and Grifola frondosa (Gf) (3%), all of which have immunomodulating properties. Whereas He and Gf have been used in traditional Chinese and Japanese medicine against cancer, AbM originates from Brazilian rain forest and was used locally and later abroad as health food for the prevention of a range of diseases, including chronic hepatitis, diabetes and cancer. The mushrooms’ health effects are probably due to their content of -glucans and other smaller immunomodulating polysaccharides and proteoglucans. These effects are mediated through their stimulation of innate immune cells, such as monocytes, NK cells and dendritic cells, and the amelioration of a skewded Th1/Th2 balance and of inflammation. Here, we give an overview of the anti-allergic effects of Andosan™ in a mouse model for allergy and anti-inflammatory effects both in vitro, in healthy individuals and in patients with inflammatory bowel diseases.


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