alexa Androgen Receptor Signaling in Prostate Cancer: New Twi
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
Open Access

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Review Article

Androgen Receptor Signaling in Prostate Cancer: New Twists for an Old Pathway

Junjie Feng1,2, S Lilly Zheng1,2, Wennuan Liu1,2, William B. Isaacs3 and Jianfeng Xu1,2,4*

1Center for Cancer Genomics, Wake Forest School of Medicine, Winston-Salem, NC, USA

2Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA

3Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA

4Van Andel Research Institute, Grand Rapids, MI, USA

Corresponding Author:
Dr. Jianfeng Xu
Center for Cancer Genomics
Medical Center Blvd, Winston-Salem, NC 27157
Tel: (336) 713-7500
Fax: (336) 713-7566
E-mail: [email protected]

Received Date: August 15, 2011; Accepted Date: September 22, 2011; Published Date: September 29, 2011

Citation: Feng J, Zheng SL, Liu W, Isaacs WB, Xu J (2011) Androgen Receptor Signaling in Prostate Cancer: New Twists for an Old Pathway. J Steroids Hormon Sci S2:001. doi: 10.4172/2157-7536.S2-001

Copyright: © 2011 Feng J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

 Secretory leukocyte protease inhibitor is a multifunctional protein with a variety of activities attributed to it. A significant increase in the expression of Secretory leukocyte protease inhibitor was noticed in syncytiotrophoblasts following differentiation of cytotrophoblasts in to syncytiotrophoblasts by addition of Forskolin. Using the BeWo cells which are derived from choriocarcinoma, the effect of addition of progesterone and estradiol on the expression of Secretory leukocyte protease inhibitor by Reverse Transcription Polymerase Chain Reaction was assessed. It was found that while addition of low concentration of progesterone resulted in a significant increase in expression of Secretory leukocyte protease inhibitor, addition of estradiol even at high concentration had no effect. The specificity of effect of progesterone was established by the observation that addition of Progesterone along with progesterone receptor antagonist (RU484) resulted in decrease in the level of expression of Secretory leukocyte protease inhibitor. These results suggest that Secretory protease leukocyte protease inhibitor is a progesterone regulated gene.

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