alexa Androgen Therapy in Adolescents: A Review | OMICS International | Abstract
ISSN: 2167-0250

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Androgen Therapy in Adolescents: A Review

Ashraf T Soliman1*, Vincenzo De Sanctis2 and Mohamed Yassin3
1Department of Pediatrics, Division of Endocrinology, Hamad Medical Center, Doha, Qatar
2Department of Pediatrics and Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara, Italy
3Department of Hematology, Alamal Hospital, Doha, Qatar
*Corresponding Author : Ashraf T Soliman
MD PhD FRCP
Professor and Senior Consultant
Pediatrics and Endocrinology
Weill Cornell Medical College-Qatar
Hamad Medical Center
P O Box 3050 Doha, Qatar
Tel: +974-55983874
E-mail:[email protected]
Received August 07, 2014; Accepted October 22, 2014; Published October 30, 2014
Citation: Soliman AT, De Sanctis V, Yassin M (2014) Androgen Therapy in Adolescents: A Review. Andrology 3:124. doi:10.4172/2167-0250.1000124
Copyright: ©2014 Soliman AT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Constitutional Delay of Growth and Puberty (CDGP) and hypogonadism are the two most common indications for Testosterone (T) therapy in adolescents. CDGP is a transient state of hypogonadotropic hypogonadism associated with prolongation of childhood phase of growth, delayed skeletal maturation, delayed and attenuated pubertal growth spurt. In pre-pubertal male with CDGP, T therapy can be used to induce pubertal development, accelerate growth and relieve the psychosocial complaints. However, some issues in the management are still unresolved. These include type, optimal timing, dose and duration of sex steroid treatment and the possible use of adjunctive or alternate therapy. In adolescents with permanent hypogonadism T therapy is used to induce then maintain pubescent development. Testosterone therapy enables the patient to decrease mood disturbances, fatigue, impaired virilization and osteoporosis. The use of anabolic drugs to enhance athletic performance has become a major concern for professional sport organizations, sport governing bodies and governments. This mini review aims at providing an update for androgen therapy in adolescents. Endocrinologists and physicians should be acquainted with the indications, the forms, optimal timing, monitoring, dose titration and possible side-effects of T therapy to accomplish the best pharmacological outcome. In addition, it is believed that through education and research we can mitigate the abuse of androgens by adolescent athletes.

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