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Angioedema-Induced By Angiotensin Converting Enzyme Inhibitors | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Angioedema-Induced By Angiotensin Converting Enzyme Inhibitors

Blum Arnon*
Interdisciplinary Stem Cell Institute, University of Miami, Miami, Florida 33136, USA
Corresponding Author : Arnon Blum
Interdisciplinary Stem Cell Institute
University of Miami, Florida, USA 33136
E-mail: [email protected]
Received May 05, 2012; Accepted June 12, 2012; Published June 22, 2012
Citation: Blum A (2012) Angioedema-Induced by Angiotensin Converting Enzyme Inhibitors. J Clin Case Rep 2:153. doi:10.4172/2165-7920.1000153
Copyright: © 2012 Blum A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Angioedema is a known allergic reaction to many medications. Angiotensin Converting Enzyme Inhibitors (ACE-I) have been reported to cause such an adverse event, however, the mechanism of action is not clear enough. ACE-I induced angioedema is often misdiagnosed, although it could develop to a life-threatening situation. It is believed that it is caused by bradykinin induced activation of vascular bradykinin B2 receptors. Studies have reported an incidence of angioedema of 1 in 1000 during the first week of use, and 1 to 42,000 subsequently. Life threatening airway obstruction requiring intubation has been reported in up to 22% of angioedema cases caused by ACE inhibitors, with an overall mortality rate of 11%.


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