alexa Angiopoietin-like Protein 4 and the level of Free Fatty Acids in Human Blood Plasma: Is there a link? | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Angiopoietin-like Protein 4 and the level of Free Fatty Acids in Human Blood Plasma: Is there a link?

Faisal H H Ali1,2* and Yazan Ranneh1

1Department of Nutrition and Dietetics, Faculty of medicine and health sciences, Nutrigenomics Programme, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

2Metabolism and genomics group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands

*Corresponding Author:
Faisal H H Ali
Metabolism and genomics group
Division of Human Nutrition
Wageningen University, Bomenweg 2
6703 HD Wageningen, The Netherlands
Tel: +60389472435
Fax: +60389426769
E-mail: [email protected]

Received date: September 05, 2013; Accepted date: September 27, 2013; Published date: September 30, 2013

Citation: Ali FHH, Ranneh Y (2013) Angiopoietin-like Protein 4 and the level of Free Fatty Acids in Human Blood Plasma: Is there a link? Med chem 3:276-281. doi:10.4172/2161-0444.1000151

Copyright: © 2013 Ali FHH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Angiopoietin-like protein 4 (Angptl4) is a new circulating protein of the Angiopoietin-like family, predominantly expressed in adipose tissue and liver. A link between Angptl4 and the levels of free fatty acids in human blood plasma remains unclear. Therefore, we hypothesized that any alteration in the concentration of plasma Angptl4 may be mediated by changes in plasma free fatty acid levels in healthy individuals.

Methods: To examine the effect of plasma free fatty acid levels on Angptl4 concentrations in humans, ELISA method was developed and used for the quantitative determination of human Angptl4 in plasma samples with known free fatty acid concentrations.

Results: It was clearly observed that there were significant (P. value<0.01) positive correlation between plasma Angptl4 concentrations and plasma levels of free fatty acid (0.905 ≤ r ≤ 1.00) and the standard curve using the human recombinant Angptl4 fragments yielded a consistent r 2 value>0.993. Raising plasma fatty acids resulted in an increase in the levels of Angptl4. While, lowering plasma fatty acids resulted in a decrease in the levels of Angptl4.

Conclusion: The results of this study indicate that changes in plasma free fatty acid levels are associated with alterations in the concentrations of Angptl4.


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