alexa Angiotensin II as an Inducer of Atherosclerosis: Eviden
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

Angiotensin II as an Inducer of Atherosclerosis: Evidence from Mouse Studies

Maxime Pellegrin and Lucia Mazzolai*
Division of Angiology, University Hospital of Lausanne, Lausanne, Switzerland
Corresponding Author : Lucia Mazzolai
Division of Angiology, Centre Hospitalier Universitaire Vaudois (Nestlé 06)
Av. Pierre-Decker 5, 1011 Lausanne, Switzerland
Tel: +41-21-3140750
Fax: +41-21-3140761
E-mail: [email protected]
Received: April 10, 2013; Accepted: May 22, 2013; Published: May 25, 2013
Citation:Pellegrin M, Mazzolai L (2013) Angiotensin II as an Inducer of Atherosclerosis: Evidence from Mouse Studies. J Clin Exp Cardiolog S1:007. doi:10.4172/2155-9880.S1-007
Copyright: © 2013 Pellegrin M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Mechanisms responsible for atherosclerotic plaque development, destabilization, and rupture are still largely unknown. Angiotensin II, the main bioactive peptide of renin angiotensin system, has been shown to be critically involved in the pathogenesis of atherosclerosis and vulnerable plaque. Experimental studies in hypercholesterolemic mouse models with high circulating Angiotensin II levels, provide direct evidence that Angiotensin II induces plaque vulnerability partly by 1/ downregulating vascular expression of anti-atherosclerotic genes and/or upregulating expression of pro-atherosclerotic genes, and 2/ skewing the systemic lymphocyte Th1/Th2 balance towards a proinflammatory Th1 response in early disease phase. Further understanding the pro-atherosclerotic mechanisms of Angiotensin II and associated signaling pathways will help to design better therapeutic strategies for reducing the burden of atherosclerotic cardiovascular disease.

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