Angiotensinogen M235T, ÃÂ²2 Adrenergic Receptor Arg16Gly and Aldosterone Synthase C-344T Gene Polymorphisms and Essential Hypertension among Han Population Living at High Altitude in China
- *Corresponding Author:
- Xinghui Li
Department of Cardiology
Gansu Provincial Hospital No. 204
Donggang West Road, Lan Zhou
Gan Su, 730000, China
E-mail: [email protected]
Received date April 05, 2016; Accepted date April 27, 2016; Published date May 07, 2016
Citation: Li X, Qiao Y, Li Y, Cai H, He J (2016) Angiotensinogen M235T, β2 Adrenergic Receptor Arg16Gly and Aldosterone Synthase C-344T Gene Polymorphisms and Essential Hypertension among Han Population Living at High Altitude in China. J Hypertens 5:222. doi:10.4172/2167-1095.1000222
Copyright: © 2016 Li X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
We explored the association of angiotensinogen (AGT) M235T, β2 adrenergic receptor (β2-AR) Arg16Gly and aldosterone synthase (CYP11B2) C-344T genes polymorphisms with essential hypertension (EH) in Han population living at high altitude in China. A total of 390 hypertensive subjects (males, 207; females, 183) and 424 normal healthy individuals (males, 251; females, 173) were enrolled in this study based on the inclusion and exclusion criteria. The polymorphisms of AGT M235T, β2-AR Arg16Gly, CYP11B2 C-344T genes were analyzed by Snapshot mini sequencing method. The frequencies of CC genotype and C allele of AGT M235T in EH group were higher than in control (p<0.05), gender wise analysis revealed that the genotype and allele patterns between patients and controls were found to be significantly different (p<0.05). However, genotype and allele frequencies of the distribution of β2-AR Arg16Gly and CYP11B2 C-344T between EH patients and normotensive controls were not significantly different (p>0.05, respectively), in gender-specific analysis, the differences were also not found (p>0.05, respectively). This finding suggests that the polymorphism of AGT M235T was correlated with EH in Han population living at high altitude in China, however, β2-AR Arg16Gly and CYP11B2 C-344T polymorphism were unlikely to associated with hypertensive subjects of this population.