Animal study of Anthracycline-induced Cardiotoxicity and Nephrotoxicity and Evaluation of Protective AgentsAmani N. Shafik1, Mostafa M. Khodeir2* and Mostafa S. Fadel3
- *Corresponding Author:
- Dr. Mostafa Mahmoud Khodeir
8 B el Malek el Naser Street, Khayrat Street
E-mail: [email protected]
Received date: February 21, 2011; Accepted date: March 24, 2011; Published date: May 15, 2011
Citation: Shafik AN, Khodeir MM, Fadel MS (2011) Animal study of Anthracyclineinduced Cardiotoxicity and Nephrotoxicity and Evaluation of Protective Agents. J Cancer Sci Ther 3: 096-103. doi: 10.4172/1948-5956.1000068
Copyright: © 2011 Shafik AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Study background: Anticancer chemotherapy Anthracycline (ANT) antibiotics associated with cardiac and renal toxicity which represents serious complication. In this study, the protective effect of the 2 beta-blockers carvedilol and nebivolol were tested in a rat model of ANT induced cardio and renal-toxicity by repeated intraperitoneal doxorubicin (Dox) administration. Methods: Six groups of animals were used, each 8 rats divided as control group- received intraperitoneal saline every other day; control carvedilol: rats received carvedilol dose 30mg/kg/day orally; control nebivolol: rats received nebivolol 1mg/kg/day orally; doxorubicin alone: a dose of 3 mg/kg/day was administered intraperitoneal every other day; doxorubicin + carvedilol: carvedilol started at the same day with Dox; doxorubicin + nebivolol: nebivolol started at the same day with Dox. All substances were administered for 12 days. Detection & quantification of doxorubicin-induced heart and renal damage and therapeutic action of beta-blockers was done using Langendorff's technique, echo-cardiographic function examinations, serum creatinine, total proteins and histopathology. Results: The administration of doxorubicin in the dose of 3 mg/kg/day for 12 days produced pronounced heart impairment, as well as renal nephrotoxic changes. Significant reduction of Doxo-cardiotoxicity and nephrotoxicity in Nebivolol-treated animals more than Carvedilol treated animals. Conclusions: Coadministration of either carvedilol or nebivolol with doxorubicin was able to ameliorate up to almost contradict doxorubicin-induced myocardial injury, glomerular filtration disturbance and renal tubular damage with upper hand for nebivolol. So, they can be considered a feasible candidate to protect against nephrotoxicity & cardiotoxicity commonly encountered with doxorubicin treatment.