alexa Anionic Polysaccharides From Phototrophic Microorganism
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

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Research Article

Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Aleksandar Radonic1§, Stefanie Thulke2§, John Achenbach1, Andreas Kurth1, Anna Vreemann1, Tanja König3, Christian Walter3, Kurt Possinger2, Andreas Nitsche1*

1Centre for Biological Security 1, Robert Koch-Institut, Berlin, Germany

2Oncology – Hematology, Charité – Universitätsmedizin Berlin, Berlin, Germany

3Institute of Bioprocess Engineering, Universität Erlangen-Nürnberg, Germany

§Authors with equal contribution.

*Corresponding Author:
Dr. Andreas Nitsche
Centre for Biological Security 1, Robert Koch-Institut
Nordufer 20, 13353 Berlin, Germany
Tel: +49 30 18754 2313
Fax: +49 30 18754 2605
E-mail: [email protected]

Received Date: November 11, 2010; Accepted Date: December 28, 2010; Published Date: December 30, 2010

Citation: Radonic A, Thulke S, Achenbach J, Kurth A, Vreemann A, et al. (2010) Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus. J Antivir Antiretrovir 2: 051-055. doi: 10.4172/jaa.1000023

Copyright: © 2010 Radonic A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of the present study was to characterise anti-vaccinia virus activities of anionic exopolysaccharides TK V3 isolated from cyanobacterium Arthrospira platensis and an exopolysaccharide isolated from the rhodophyt Porphyridium purpureum, respectively. These substances have previously been shown to be active against other enveloped viruses. We determined the in vitro inhibition of GFP-expressing vaccinia virus replication of 50% at a concentration of 0.65 µg/ ml for EPS and of 0.78 µg/ml for TK V3. Substances also had an antiviral effect against ectromelia virus which is a most distinct orthopoxvirus genetically and the causative agent of mousepox. Anti-vaccinia virus and anti-ectromelia virus activities were demonstrated to increase with decreasing multiplicity of infection. Furthermore, non-toxic reduction of vaccinia virus in ovo replication was shown. Using time-of-addition assays, inhibition of viral entry by polyanionic substances was verified. EPS and TK V3 derived from phototrophic microorganisms represent novel anti-orthopoxvirus substances.

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