alexa Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment

Yong S Shim1, Bora Yoon2, Yun Jeong Hong3, A-Hyun Cho1, Dong Suk Shim1, Hae Eun Shin1, Dong Won Yang1*

1Department of Neurology, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea

2Department of Neurology, Konyang University College of Medicine, 158 Gwangeodong-ro, Seo-gu, Daejeon 302-718, Korea

3Department of Neurology, Yong-In Hyoja Geriatric Hospital, 1-30, Jungbu-daero 874beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 446-512, Korea

Corresponding Author:
Dong-Won Yang
Department of Neurology
Seoul St’ Mary’s Hospital
College of Medicine
The Catholic University of Korea College of Medicine
222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea
Tel: 82-2-258-6077
Fax: 82-2-599-9686
E-mail: [email protected]

Received date: August 03, 2014; Accepted dat: October 10, 2014; Published date: October 15, 2014

Citation: Shim YS, Yoon B, Hong YJ, Cho AH, Shim DS, et al. (2014) Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment. J Neurol Neurophysiol 5:239. doi:10.4172/2155-9562.1000239

Copyright: © 2014 Shim YS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Vascular disease is associated with cognitive impairment. White matter hyperintensities (WMHs), as detected by
brain magnetic resonance imaging (MRI), are associated with cognitive impairment and considered to be a marker
of cerebral microvascular abnormality. Ankle-brachial pressure index (ABI) and pulse wave velocity (PWV) are noninvasive
methods to assess blockage and stiffness in peripheral arteries, respectively. We investigated the
associations of ABI and PWV with WMHs and cognition. We included 242 subjects representing 56 controls, 75
patients with mild cognitive impairment, and 111 patients with Alzheimer’s disease. We assessed brachial-ankle
PWV (baPWV), ABI, general cognitive status with the Korean Mini-Mental State Examination (K-MMSE), and WMHs
with brain MRI. The mean age of subjects correlated with values of baPWV (r=0.432, p<0.001) and ABI (r=-0.192,
p=0.002). Among vascular risk factors, baPWV was positively associated with the presence of intracerebral artery
stenosis (r=0.102, p=0.028) and ABI was negatively correlated with the presence of hypertension (r=-0.150,
p=0.017) and smoking (r=-0.176, p=0.005), independent of age. After adjusting for age and vascular risk factors,
baPWV was associated with WMHs (r=0.192, p=0.002), and ABI was associated with the K-MMSE score (r=0.14,
p=0.028). There was no association of ABI with WMHs and of baPWV with K-MMSE. An increased baPWV was
associated with the severity of WMHs, and a lower ABI was associated with cognitive impairment. Management of
peripheral vascular disease may help prevent the progression of WMHs or cognitive decline.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version