alexa Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment

Yong S Shim1, Bora Yoon2, Yun Jeong Hong3, A-Hyun Cho1, Dong Suk Shim1, Hae Eun Shin1, Dong Won Yang1*

1Department of Neurology, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea

2Department of Neurology, Konyang University College of Medicine, 158 Gwangeodong-ro, Seo-gu, Daejeon 302-718, Korea

3Department of Neurology, Yong-In Hyoja Geriatric Hospital, 1-30, Jungbu-daero 874beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 446-512, Korea

Corresponding Author:
Dong-Won Yang
Department of Neurology
Seoul St’ Mary’s Hospital
College of Medicine
The Catholic University of Korea College of Medicine
222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea
Tel: 82-2-258-6077
Fax: 82-2-599-9686
E-mail: [email protected]

Received date: August 03, 2014; Accepted dat: October 10, 2014; Published date: October 15, 2014

Citation: Shim YS, Yoon B, Hong YJ, Cho AH, Shim DS, et al. (2014) Ankle-Brachial Pressure Index and Pulse Wave Velocity as Markers of White Matter Hyperintensities and Cognitive Impairment. J Neurol Neurophysiol 5:239. doi:10.4172/2155-9562.1000239

Copyright: © 2014 Shim YS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Vascular disease is associated with cognitive impairment. White matter hyperintensities (WMHs), as detected by
brain magnetic resonance imaging (MRI), are associated with cognitive impairment and considered to be a marker
of cerebral microvascular abnormality. Ankle-brachial pressure index (ABI) and pulse wave velocity (PWV) are noninvasive
methods to assess blockage and stiffness in peripheral arteries, respectively. We investigated the
associations of ABI and PWV with WMHs and cognition. We included 242 subjects representing 56 controls, 75
patients with mild cognitive impairment, and 111 patients with Alzheimer’s disease. We assessed brachial-ankle
PWV (baPWV), ABI, general cognitive status with the Korean Mini-Mental State Examination (K-MMSE), and WMHs
with brain MRI. The mean age of subjects correlated with values of baPWV (r=0.432, p<0.001) and ABI (r=-0.192,
p=0.002). Among vascular risk factors, baPWV was positively associated with the presence of intracerebral artery
stenosis (r=0.102, p=0.028) and ABI was negatively correlated with the presence of hypertension (r=-0.150,
p=0.017) and smoking (r=-0.176, p=0.005), independent of age. After adjusting for age and vascular risk factors,
baPWV was associated with WMHs (r=0.192, p=0.002), and ABI was associated with the K-MMSE score (r=0.14,
p=0.028). There was no association of ABI with WMHs and of baPWV with K-MMSE. An increased baPWV was
associated with the severity of WMHs, and a lower ABI was associated with cognitive impairment. Management of
peripheral vascular disease may help prevent the progression of WMHs or cognitive decline.

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