alexa Ankylosing Spondylitis in Association with Non-Hodgkin's Lymphoma : Successful Anti-TNF Alpha Treatment | OMICS International | Abstract
ISSN: 2165-7939

Journal of Spine
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Case Report

Ankylosing Spondylitis in Association with Non-Hodgkin's Lymphoma : Successful Anti-TNF Alpha Treatment

Augusta Ortolan1, Anna La Salvia2, Mariagrazia Lorenzin1, Paola Frallonardo1, Dario Marino2, Leonardo Punzi1 and Roberta Ramonda1*
1Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy
2Department of Oncology, Istituto Oncologico Veneto (IOV), IRCCS, University of Padova, Padova, Italy
Corresponding Author : Roberta Ramonda MD PhD
Rheumatology Unit, Department of Medicine DIMED Via Giustiniani 2
35128 Padova, Italy
Tel: +39049 8212199
Fax: +39049 8212191
E-mail: [email protected]
Received: December 03, 2015 Accepted: December 19, 2015 Published: December 21, 2015
Citation: Ortolan A, La Salvia A, Lorenzin M, Frallonardo P, Marino D, et al. (2015) DAnkylosing Spondylitis in Association with Non-Hodgkin’s Lymphoma: Successful Anti-TNF Alpha Treatment. J Spine 4:272.doi:10.4172/2165-7939.1000272
Copyright: © 2015 Ortolan A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Some rheumatic diseases, including ankylosing spondylitis, appear to be associated to an increased risk of cancer, in particular lymphoma. At the same time, a slightly higher risk of cancer has been associated to Tumour Necrosis Factor (TNF)-alpha antagonists, a widely used treatment for ankylosing spondylitis. A history of malignancy is generally considered a contraindication to TNF-alpha inhibitor and, if neoplasia is uncovered during treatment, therapy suspension is mandatory. Few data are available regarding the possibility of resuming treatment in the event of a flare up of this disease, even when exams monitoring the neoplastic disease are negative. Here we describe the case of a 56-year-old AS patient who developed a cutaneous B-cell non-Hodgkin lymphoma while undergoing treatment with a TNF-alpha inhibitor. The therapy was suspended while he was treated for the neoplasia, but it was resumed when there was a flare up of the disease, and the patient showed improvement.

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