alexa Anthelmintic Activities of Aqueous and Methanol Extracts of Prunella vulgaris L.
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Anthelmintic Activities of Aqueous and Methanol Extracts of Prunella vulgaris L.

Bashir A Lone1*, Chishti MZ1, Bhat FA2, Tak H2, Bandh SA3 and Khan A2

1Parasitology Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India

2Department of Zoology, University of Kashmir, Srinagar, Jammu and Kashmir, India

3Microbiology Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India

*Corresponding Author:
Dr. Bashir A Lone
Parasitology Research Laboratory, Centre of Research for Development
University of Kashmir, Srinagar-190 006, Jammu and Kashmir, India
Tel: +919419384472
E-mail: [email protected]

Received Date: April 23, 2017; Accepted Date: May 03, 2017; Published Date: May 08, 2017

Citation: Lone BA, Chishti MZ, Bhat FA, Tak H, Bandh SA, et al. (2017) Anthelmintic Activities of Aqueous and Methanol Extracts of Prunella vulgaris L. Nat Prod Chem Res 5:269. doi: 10.4172/2329-6836.1000269

Copyright: © 2017 Lone BA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The increasing anthelmintic resistance, drug residues in animal products and high cost of conventional anthelmintics has created an interest in studying medicinal plants as an alternative source of anthelmintics. The aqueous and methanolic extracts of Prunella vulgaris was evaluated for anthelmintic efficacy against gastrointestinal nematodes of sheep under both in vitro and in vivo conditions using worm motility inhibition assay, egg hatch assay and faecal egg count reduction percent (FECR%) assay respectively. Crude methanol extract and crude aqueous extract of P. vulgaris resulted in mean percentage mortality of 94.44%, as observed after the worms were put in lukewarm PBS for 30 min after exposure to different treatments(p<0.01). Crude methanol extract (LC50=2.48 mg/mL) had higher inhibitory effects compared to that of crude aqueous extract (LC50=3.36 mg/mL) on egg hatching, exhibiting higher ovicidal activity. in vivo, maximum reduction (92.86%) in faecal egg counts was recorded for crude methanol extract, followed by crude aqueous extract (80.34%) with dose 2 g/kg of body weight at day 15 post-treatment. The results of the present study suggest that P. vulgaris extracts are promising alternatives to the commercially available anthelmintics for the treatment of sheep nematodes.

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