alexa Anti-Aβ Antibodies in the Fighting with Alzheimer's Disease
ISSN: 2168-9431

Single Cell Biology
Open Access

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Review Article

Anti-Aβ Antibodies in the Fighting with Alzheimer's Disease

Mehmet Bostanciklıoglu*
Faculty of Medicine, Department of Physiology, Gaziantep University, Gaziantep, Turkey
Corresponding Author : Mehmet Bostanciklioglu
Department of Physiology, Faculty of Medicine
Gaziantep University, Gaziantep, Turkey
Tel: +90342 360 12 00
Fax: +90342 360 10 13
E-mail: [email protected]
Received December 20, 2015; Accepted January 23, 2016; Published January 25, 2016
Citation:Bostanciklıoglu M (2016) Anti-Aβ Antibodies in the Fighting with Alzheimer’s Disease Single Cell Biol 5:127. doi:10.4172/2168-9431.1000127
Copyright: © 2016 Bostanciklıoglu M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Alzheimer disease (AD) is the most common form of dementia. Amyloid-β plaques have become main therapeutic targets on the basis of growing evidences. Despite hundred studies are designed in animals and humans, the success in this therapeutic approach is still a disappointment. In the present study, the affect mechanism of anti-Aβ antibodies, the type of antibodies and immunization, why despite numerous studies and the huge budget allocated for the researches of AD, the treatment success is limited also what is the last developments in the immunotherapeutic, are reviewed. The necessity of the early treatment of AD is stronger than ever. Therefore, the new studies which target to develop the new conformation specific antibodies and the new techniques that facilitate the crossing of these new conformation specific antibodies to central nervous system (CNS) through blood brain barrier (BBB) should be designed.

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