alexa Anti-Anxiety Effects of Mercurialis annua Aqueous Extra

Journal of Pharmacological Reports
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Research Article

Anti-Anxiety Effects of Mercurialis annua Aqueous Extract in the Elevated Plus Maze Test

Zouhra Doukkali1*, Rabie Kamal1, Meryem El Jemelif1, Mohamed Nadjmouddine1, Amina Zellou1, Yahya Cherrah1, Katim Alaoui1 and Khalid Taghzouti2
1Pharmacodynamy Research Team, ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V of Rabat, Morocco
2Laboratory of Animal Physiology, Department of Biology, Faculty of Science, University Mohammed V of Rabat, Morocco
Corresponding Author : Zouhra Doukkali
Pharmacodynamy Research Team, ERP
Laboratory of Pharmacology and Toxicology
Faculty of Medicine and Pharmacy
University Mohammed V of Rabat, Morocco
Tel: +33 (0)5 57 57 10 10
E-mail: [email protected]
Received December 10, 2015; Accepted January 07, 2016; Published January 11, 2016
Citation: Doukkali Z, Kamal R, Jemeli ME, Nadjmouddine M, Zellou A, et al. (2016) Anti-Anxiety Effects of Mercurialis annua Aqueous Extract in the Elevated Plus Maze Test. J Pharma Reports 1:104. doi:10.4172/jpr.1000104
Copyright: © 2016 Doukkali Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: The most widely prescribed medications for anxiety disorders are the Benzodiazepines; however, they have prominent side effects. Therefore, the development of new pharmacological agents is well justified and interest in alternative medicine that affects the ‘mind’ is growing. Among medicinal plants, Mercurialis annua has been recommended for relief of anxiety in Morocco folk medicine. Method: The present study was undertaken to investigate the effects of methanolic extract of Mercurialis annua in the elevated plus maze (EPM) and Open Field (OF) models of anxiety. The Mercurialis annua extract was administered orally to Balb/c mice, at graded doses and diazepam was given intraperitonealy. Result: In the EPM, methanolic extract at 200-400 mg/kg showed an anxiolytic effect by increasing the time spent on open arms and the percentage of open arm entries compared to control group. In an open field test methanolic extract of M.a (400 mg/kg) increased the central area crossing, the time spent and number of rearing in the center of arena. Conclusion: These data support that the methanolic extract of M.a might possess significant anxiolytic potential to be pursued further for drug development process and provide a scientific evidence for its traditional claim.

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