alexa Antiarthritic Effects of Daphne giraldii Nitsche (Thymelaeaceae) Mainly through Suppression of the Secondary Inflammation | OMICS International | Abstract
ISSN: 2471-2698

Pharmaceutical Analytical Chemistry: Open Access
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Research Article

Antiarthritic Effects of Daphne giraldii Nitsche (Thymelaeaceae) Mainly through Suppression of the Secondary Inflammation

Sheng Wang1,2, Xiaotao Xu1,2, Yue Zang1,2, Xiaoxing Huang1,2, Yifei Wang1,2, Bin Zheng1,2, Li Liu1,2* and Qibing Mei1,2*

1China State Institute of Pharmaceutical Industry, Shanghai, China

2State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai, China

*Corresponding Author`s:
Qibing Mei, PhD
State Key Laboratory of New Drug and Pharmaceutical Process
Shanghai Institute of Pharmaceutical Industry
China State Institute of Pharmaceutical Industry
No. 1 Zhongshan North Road
Hongkou District, Shanghai, 200437, China
Tel: 021-65449361
Fax: 86 2165449361
E-mail: [email protected]
Li Liu, PhD
State Key Laboratory of New Drug and Pharmaceutical
Shanghai Institute of Pharmaceutical Industry
China State Institute of Pharmaceutical Industry
No. 1 Zhongshan North Road, Hongkou District
Shanghai, 200437, China
Tel: 021-55514600
Fax: 86 2155514600
E-mail: [email protected]

Received date: November 09, 2015; Accepted date: November 17, 2015; Published date: November 20, 2015

 

Citation: Wang S, Xu X, Zang Y, Huang X, Wang Y, et al. (2015) Antiarthritic Effects of Daphne giraldii Nitsche (Thymelaeaceae) Mainly through Suppression of the Secondary Inflammation. Pharm Anal Chem Open Access 1:107. doi: 10.4172/2471-2698.1000107

 

Copyright: © 2015 Wang S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The present study focuses on the anti-arthritic effect of Zushima cataplasms (ZC) in adjuvant arthritic (AA) rats. AA rats were treated with ZC from the 3rd day before immunization and continued until the 20th day after immunization. The severity of arthritis was evaluated by swelling, heat, nociceptive, histopathology and radiological changes. The levels of IL-1β, TNF-α in the serum were measured by ELISA. ZC showed no effect on alleviating swelling in primary inflammation, while ZC 0.75 g/kg dramatically reduced the swelling, and showed a significant increment of mechanical pain thresholds in secondary inflammation. The synovial hyperplasia and inflammatory cells infiltration were suppressed by ZC in secondary inflammation but not in primary inflammation. The radiographic studies further provided supportive evidence for histopathology analysis. Additionally, There was significant reduction in production of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) in serum of AA rats treated with ZC.

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