Antibacterial Activity of Rhazya stricta Non-alkaloid Extract against Methicillin-Resistant Staphylococcus aureus
- *Corresponding Author:
- Raziuddin Khan
Department of Biological Sciences, Faculty of Sciences
King Abdulaziz University, Jeddah, Saudi Arabia
E-mail: [email protected]
Received date: March 08, 2016; Accepted date: April 02, 2016; Published date: May 29, 2016
Citation: Khan R, Baeshen MN, Saini KS, Bora RS, Al-Hejin AM, et al. (2016) Antibacterial Activity of Rhazya stricta Non-alkaloid Extract against Methicillin-Resistant Staphylococcus aureus. Biol Syst Open Access 5:157. doi:10.4172/2329-6577.1000157
Copyright: © 2016 Khan R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The effect of a crude, organic, non-alkaloid extract derived from R. stricta leaves were evaluated against methicillin-resistant Staphylococcus aureus (MRSA) pathogens. Antibacterial activities were determined by zones of inhibition using a new 1% agarose well-diffusion method. Structural and morphological alterations of MRSA cells were investigated using transmission electron microscopy. The extract showed antibacterial activities against MRSA pathogens. The extract inhibited growth, with zones of inhibition ranging between 6 and 19 mm. Transmission electron microscopy revealed that the extract distorts the cellular architecture of MRSA pathogens. Crude organic non-alkaloid extract derived from R. stricta leaves might serve as a novel antibiotic agent to prevent or treat lifethreatening MRSA infections.