alexa Antibacterial and Anti-Acanthamoebic Properties of Catha Edulis (Khat) | OMICS International | Abstract
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Antibacterial and Anti-Acanthamoebic Properties of Catha Edulis (Khat)

Ruqaiyyah Siddiqui1, Abdi Aden Warsame2 and Naveed Ahmed Khan1*

1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan

2School of Biological and Chemical Sciences, Birkbeck, University of London, England, UK

*Corresponding Author:
Naveed Ahmed Khan
Department of Biological and Biomedical Sciences
Aga Khan University, Stadium Road, Karachi, Pakistan
Tel: 92-(0)21-3486-4540
Fax: 92-(0)21-3493-4294
E-mail: [email protected]

Received date: September 11, 2012; Accepted date: September 26, 2012; Published date: September 30, 2012

Citation: Siddiqui R, Warsame AA, Khan NA (2012) Antibacterial and Anti- Acanthamoebic Properties of Catha edulis (Khat). J Bacteriol Parasitol 3:152. doi: 10.4172/2155-9597.1000152

Copyright: ©2012 Siddiqui R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Infectious diseases remain a significant threat to human health, contributing to more than 17 million annual deaths thus indicating an urgent to identify novel molecules for antimicrobial chemotherapy. Here, the antimicrobial activities of aqueous crude extracts of Catha edulis (khat widely used in Africa and southern parts of Arabia) were tested against a panel of microorganisms including Gram-positive bacteria (Bacillus magaterium, Micrococcus luteus), Gram-negative bacteria (Escherichia coli, Brevundimonas diminuta), yeast (Aspergillus varicoluor, Penicillum solitum, Penicillum brevicompactum) and the protist (Acanthamoeba castellanii) in vitro. At 100 μg, C. edulis extracts exhibited potent antibacterial activity against B. diminuta (19 mm ± 2.3), B. magaterium (16 mm ± 0.7) and M. luteus (22 mm ± 3.1) but not against E. coli and yeast (A. varicoluor, P. solitum, P. brevicompactum). Notably, C. edulis extracts showed amoebicidal effects (>50 % reduction in amoeba numbers of the original inoculum) as evidenced by the uptake of Trypan blue dye. The remaining sub-population of A. castellanii remained viable but cultures remained static over longer incubations. These findings show that C. edulis extract possess selective antibacterial properties. For the first time, it is shown that C. edulis extract exhibit anti-Acanthamoebic properties. Further studies are needed to identify active components and assess their clinical relevance.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuropsycho[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7