alexa Antibiotic Susceptibility Profile of Escherichia coli and Salmonella Causing Childhood Diarrhoea in Awka Municipality, South-eastern Nigeria
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Research Article

Antibiotic Susceptibility Profile of Escherichia coli and Salmonella Causing Childhood Diarrhoea in Awka Municipality, South-eastern Nigeria

Ugwu MC1*, Edeani GI1, Ejikeugwu CP1,2, Okezie U1 and Ejiofor SO3

1Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Agulu Campus, Awka, Nigeria

2Department of Applied Microbiology, Ebonyi State University, P.M.B 053, Abakaliki, Nigeria

3Chukwuemeke Odumegwu Ojukwu University Teaching Hospital (COOUTH) Awka, Nigeria

*Corresponding Author:
Ugwu MC
Department of Pharmaceutical Microbiology and Biotechnology
Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University
Agulu Campus, Awka, Nigeria
Tel: +2348039460570
E-mail: [email protected]

Received date: April 1, 2017; Accepted date: April 24, 2017; Published date: April 28, 2017

Citation: Ugwu MC, Edeani GI, Ejikeugwu CP, Okezie U, Ejiofor SO (2017) Antibiotic Susceptibility Profile of Escherichia coli and Salmonella Causing Childhood Diarrhoea in Awka Municipality, South-eastern Nigeria. Clin Microbiol 6:277. doi:10.4172/2327-5073.1000277

Copyright: © 2017 Ugwu MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: In developing countries diarrheal diseases in children are a major public health concern.

Objectives: This study investigated the incidence and antibiotic susceptibility profile of Escherichia coli and Salmonella causing Childhood Diarrhea in Awka.

Methods: Twenty six (26) diarrheic stool samples were collected from children (<5) years and cultured. The isolated bacteria were subjected to various identification and biochemical tests. The 44 isolated bacteria (E. coli and Salmonella isolates) were subjected antibiotic susceptibility studies and ESBL-producing screening.

Results: E. coli and Salmonella were detected in 23 (88%) and 21 (80%) fecal specimen associated with diarrheal episodes respectively. E. coli showed 91% resistance to ceftazidime, 100% resistance to cefuroxime, 78% resistance to gentamicin, 91% resistance to ceftriaxone, 78% resistance to ofloxacin and 100% resistance to augumentin. Salmonella showed 100% resistance to ceftazidime, 100% resistance to cefuroxime, 100% resistance to gentamicin, 100% resistance to ceftriaxone, 69% resistance to ofloxacin and 82% resistance to augumentin®. Fifteen (65.2%) E. coli isolates were ESBL producers and 8 (34.7%) isolates were non-ESBL producers.

Conclusion: Overall prevalence of 88.5% of E. coli and 80.8% of Salmonella spp. were associated with childhood diarrhea in the studied locality. The E. coli and Salmonella spp. were multidrug resistant. Majority (65.2%) of the E. coli were ESBL producers thus the colonized children may be potential sources of multidrug ESBLproducing E. coli strains in the hospital and/or community.


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