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Antibodies Against Gangliosides in the Serum of Patients Suffering from Multiple Sclerosis Compared with Healthy Individuals | OMICS International | Abstract
ISSN: 2168-9784

Journal of Medical Diagnostic Methods
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Research Article

Antibodies Against Gangliosides in the Serum of Patients Suffering from Multiple Sclerosis Compared with Healthy Individuals

Euphrosyni Koutsouraki*, Eleni Hatzifilippou, Thalia Kalatha, Vassiliki Costa and Stavros Baloyannis
1stDepartment of Neurology, Aristotle University, AHEPA Hospital, St. Kyriakidi 1, 54636, Thessaloniki, Greece
Corresponding Author : Euphrosyni Koutsouraki
Assistant Professor of Neurology
Aristotle University, 1st Department of Neurology
AHEPA Hospital, St. Kyriakidi 1, 54636
Thessaloniki, Greece
Tel: 0030 2310 994604
Fax: 0030 2310994711
E-mail: [email protected]
Received August 02, 2013; Accepted September 22, 2013; Published September 28, 2013
Citation: Koutsouraki E, Hatzifilippou E, Kalatha T, Costa V, Baloyannis S (2013) Antibodies Against Gangliosides in the Serum of Patients Suffering from Multiple Sclerosis Compared with Healthy Individuals. J Med Diagn Meth 2:136. doi:10.4172/2168-9784.1000136
Copyright: © 2013 Koutsouraki E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We examined the sera of 56 patients with definite multiple sclerosis (MS) and 44 healthy individuals using ELISA, for investigating the probable correlation between IgM antibodies against GM1, GD1b and GQ1b gangliosides and clinical parameters of MS. Patients revealed pathological concentrations of the examined antibodies, while healthy controls demonstrated normal levels (p=0.0005). A probable correlation between anti-GD1b and anti-GM1 IgM levels with the progression of MS and a positive comparison between the duration and the disability have also been indicated. Further investigation should be established in order to provide insights on the potential autoantigenic role of gangliosides in MS.

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