alexa Anti-C1Q Antibodies Concentrations by Elisa in Systemic Lupus Erythematosus

Lupus: Open Access
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Research Article

Anti-C1Q Antibodies Concentrations by Elisa in Systemic Lupus Erythematosus

Audrey A Margery-Muir1*, John D Wetherall1, David M Groth1 and Christine Bundell2

1School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, GPO box U1987 Bentley Western, Australia

2PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Hospital Avenue, Nedlands, Australia

*Corresponding Author:
Audrey A Margery-Muir
School of Biomedical Sciences, Curtin University
GPO box U1987 Bentley Western, Australia 6845
Tel: +08-926-687-903
E-mail: [email protected]

Received date: March 17, 2017; Accepted date: April 19, 2017; Published date: April 25, 2017

Citation: Margery-Muir AA, Wetherall JD, Groth DM, Bundell C (2017) Anti-C1Q Antibodies Concentrations by Elisa in Systemic Lupus Erythematosus. Lupus Open Access 2:124.

Copyright: © 2017 Margery-Muir AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Systemic lupus erythematosus (SLE) is an inflammatory disorder in which autoantibodies contribute to impaired apoptosis and clearance of cell debris. Anti dsDNA and anti C1q antibodies have been implicated, as well as complement protein C1q itself. IgG autoantibodies reacting with the collagen-like region of C1q protein (αC1q ab) were quantitated in serum of 56 patients diagnosed with SLE and undergoing treatment for variable periods, together with 33 age/sex-matched controls. Analysis of the results showed optimal sensitivity and specificity of 57% and 91% respectively at a cut-off concentration for positivity of 20 U/ml. The assay is a potentially useful confirmatory test for SLE, but is not suitable as a screening test for SLE with the probability of a positive test and SLE in an individual within a random population of only ≤ 1%. αC1q ab concentrations were detectable in all samples tested with concentrations manifesting no correlation with age and serum C1q levels in SLE patients and a negative correlation with age in controls. The αC1q ab detected by this assay do not react therefore with native C1q. In SLE patients, αC1q ab concentrations correlated with the concentrations of dsDNA antibodies, (p=0.0001) and C-reactive protein and inversely with complement component C4 (C4) concentrations (p=0.041). αC1q ab concentrations were not associated with individual therapeutic regimens, but were higher in those patients receiving a combination of three drug therapies and with the presence of renal disease. The diagnostic relevance of this complex autoantibody will require further definition of its antigenic specificities.

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