alexa Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis
ISSN: 2168-9784

Journal of Medical Diagnostic Methods
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Editorial

Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis

Fariborz Ghaffarpasand*
Health Policy Research Center, Shiraz University of Medical Sciences, School of Medicine, Zand Avenue, Shiraz, Iran
Corresponding Author : Fariborz Ghaffarpasand
Health Policy Research Center
Shiraz University of Medical Sciences
School of Medicine, Zand Avenue, Shiraz, Iran
Tel: 00989173095214
Fax: 00987112309615
E-mail: [email protected], [email protected]
Received April 17, 2012; Accepted April 18, 2012; Published April 21, 2012
Citation: Ghaffarpasand F (2012) Anticyclic Citrullinated Peptide Antibody: A Predictor of Juvenile Idiopathic Arthritis Progression Toward Rheumatoid Arthritis. J Med Diagn Meth 1:e102. doi:10.4172/2168-9784.1000e102
Copyright: © 2012 Ghaffarpasand F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Rheumatoid Arthritis (RA) has been associated with several autoantibodies, including antiperinuclear factor, anti-keratin antibodies, anti-filaggrin antibodies, and anti-Cyclic Citrullinated Peptide (anti-CCP) antibodies. Most studies found that anti-CCP antibodies are only detected in Juvenile Rheumatoid Arthritis (JRA) patients with positive Rheumatoid Factor (RF). In our center we experimentally observed that children with Juvenile Idiopathic Arthritis (JIA) that tested positive for anti-CCP Abs were also tested positive for RF. In seven years of follow-up of these 86 patients, 63 (73.2%) developed RA. It can be hypothesized that the antibodies against CCP plays an important role in progression of the JIA towards RA. On the other hand anti-CCP Abs may play a role in the pathogenesis of RA. Further studies are needed to clarify this association.

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